Vitamin B complex and mood

What 2 graded rows on vitamin b complex agree on for mood, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Vitamin B complex page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Vitamin B complex page, with its PubMed record.

Supplement

Vitamin B complex Choose another

2 rows · 2,075 people

Split. 1 row found an improvement and 1 had mixed results.

Mixed

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.

From the rows

The best-graded row, grade C, is a meta-analysis of 2,015 people (2019) and reported mixed results.

The rows run from 60 to 2,015 people, published from 2011 to 2019: 1 pooled review and 1 single study.

1 improved · 1 mixed

Grade DWork-related strain and mood · Improved
RCT · n 60 · 2011 · Employed adults with work stress (Australia)
Daily high-dose B complex · 90 days
Lower personal strain and less confusion and depressed mood at 12 weeks after adjusting for personality and work demands; no changes in other mood or anxiety measures.
Row on the Vitamin B complex page · PubMed 21905094 (opens PubMed)
Grade CStress, depressive symptoms and anxiety · Mixed
Meta-analysis, 16 studies · n 2,015 · 2019 · Healthy and at-risk adults in 16 RCTs (12 meta-analysed)
Varied by trial · ≥4 weeks
Stress improved (SMD 0.23, 95% CI 0.02–0.45; n = 958); depressive symptoms did not reach significance (SMD 0.15, P = 0.07) and anxiety was unchanged (SMD 0.03).
Row on the Vitamin B complex page · PubMed 31527485 (opens PubMed)