Vitamin B complex and heart
What 2 graded rows on vitamin b complex agree on for heart, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Vitamin B complex page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Vitamin B complex page, with its PubMed record.
Your question
Vitamin B complex and heart
2 rows · 73,885 peopleThey agree: both rows found no difference.
- ∅No effect× 2
- Rows
- 2
- Trials
- 14
- People
- 73,885
- Pooled reviews may count some twice
What the rows share
From the rowsEvery row is graded No effect, our grade for adequately powered trials that found no effect.
The rows run from 5,522 to 68,363 people, published from 2006 to 2026: 1 pooled review and 1 single study.
The rows
2 no difference- ∅No effectDeath, heart attack and stroke with B-vitamin combinations (pooled trials) · No difference
Meta-analysis, 13 studies · n 68,363 · 2026 · Adults in primary and secondary prevention, 13 RCTs of at least 24 months
Varied by trial · 24 months or longer
No effect on all-cause mortality (RR 1.01), cardiovascular mortality (RR 0.97) or heart attack (RR 0.97); stroke (RR 0.91) and major cardiovascular events (RR 0.93) were not significantly lower overall. In primary prevention trials, stroke (RR 0.79) and major events (RR 0.80) were lower; in secondary prevention, major events fell modestly (RR 0.91, 95% CI 0.83–0.99).
Row on the Vitamin B complex page · PubMed 41830012 (opens PubMed)
- ∅No effectCardiovascular death, heart attack and stroke · No difference
RCT · n 5,522 · 2006 · Adults 55+ with vascular disease or diabetes
2.5 mg folic acid, 50 mg B6, 1 mg B12 daily · Mean 5 years
Homocysteine fell 2.4 µmol/L, but the composite of cardiovascular death, heart attack and stroke was unchanged (18.8% vs 19.8%; RR 0.95, 95% CI 0.84–1.07). Stroke alone was less frequent (RR 0.75) and hospitalisation for unstable angina more frequent (RR 1.24).
Row on the Vitamin B complex page · PubMed 16531613 (opens PubMed)