Type II Collagen (Undenatured) and knee osteoarthritis
What 4 graded rows on type ii collagen (undenatured) agree on for knee osteoarthritis, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Type II Collagen (Undenatured) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Type II Collagen (Undenatured) page, with its PubMed record.
Your question
Type II Collagen (Undenatured) and knee osteoarthritis
4 rows · 518 peopleMostly an improvement: 3 of 4 rows, and most of the people. 1 found no difference.
- CGrade C× 2
- DGrade D× 2
- Rows
- 4
- Trials
- 4
- People
- 518
Where they differ
From the rowsThe best-graded row, grade C, is a randomized trial of 212 people (2024) and found an improvement.
The 3 rows that found an improvement were larger: a median of 186 people, against 68 people for the row that found no difference.
The 3 rows that found an improvement ran longer (3 to 6 months) than the row that found no difference (3 months).
The row that found no difference is newer (2025) than the 3 rows that found an improvement (2009 to 2024).
The best grade is C among the rows that found an improvement, and D among the row that found no difference.
The rows
3 improved · 1 no difference- CGrade CKnee osteoarthritis pain, stiffness and function (WOMAC, KOOS) versus placebo · Improved
RCT · n 212 · 2024 · Adults aged 40 to 75 with stage II–III knee osteoarthritis at 12 Russian centres
One capsule daily (collagen content not stated in the abstract) · 180 days
The capsule beat placebo on pain, stiffness, joint function, quality of life and NSAID need, with a good safety profile.
Row on the Type II Collagen (Undenatured) page · PubMed 38829812 (opens PubMed)
- CGrade CKnee osteoarthritis symptoms (WOMAC) versus placebo and glucosamine plus chondroitin · Improved
RCT · n 186 · 2016 · Adults with moderate-to-severe knee osteoarthritis (multicentre, India)
40 mg/day · 180 days
Total WOMAC fell more than with placebo (P = 0.002) and with glucosamine 1,500 mg plus chondroitin 1,200 mg (P = 0.04), with gains in pain, stiffness and function subscales. Adverse events: 13% UC-II, 12% placebo, 31% glucosamine plus chondroitin.
Row on the Type II Collagen (Undenatured) page · PubMed 26822714 (opens PubMed)
- DGrade DKnee osteoarthritis symptoms versus glucosamine plus chondroitin · Improved
RCT · n 52 · 2009 · Adults with knee osteoarthritis
40 mg/day UC-II (10 mg undenatured collagen) · 90 days
WOMAC fell 33% with UC-II versus 14% with glucosamine plus chondroitin, with similar differences in pain (VAS) and Lequesne scores.
Row on the Type II Collagen (Undenatured) page · PubMed 19847319 (opens PubMed)
- DGrade DKnee osteoarthritis pain and function (UC-II plus hydrolysed collagen) · No difference
RCT · n 68 · 2025 · Adults with knee osteoarthritis (Thailand)
20 mg UC-II plus 480 mg hydrolysed collagen per day (two tablets at bedtime) · 12 weeks
Pain, KOOS function, rescue-medication use and satisfaction improved in both groups with no difference from placebo; no adverse effects were reported.
Row on the Type II Collagen (Undenatured) page · PubMed 40897777 (opens PubMed)