Type II Collagen (Undenatured) and joint comfort

What 3 graded rows on type ii collagen (undenatured) agree on for joint comfort, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Type II Collagen (Undenatured) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Type II Collagen (Undenatured) page, with its PubMed record.

Supplement

Type II Collagen (Undenatured) Choose another

3 rows · 209 people

They agree: all 3 rows found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade C, is a randomized trial of 96 people (2022) and found an improvement.

The rows run from 55 to 96 people, published from 2013 to 2023: 3 single studies.

3 improved

Grade CKnee range of motion in healthy adults with activity-related joint discomfort · Improved
RCT · n 96 · 2022 · Healthy adults aged 20–55 with activity-related knee discomfort
40 mg/day · 24 weeks
Knee flexion improved more than with placebo (3.23° vs 0.21°, P = 0.025); extension improved within the UC-II group only.
Row on the Type II Collagen (Undenatured) page · PubMed 35377244 (opens PubMed)
Grade CKnee range of motion, knee and lower-back discomfort (NEXT-II) · Improved
RCT · n 58 · 2023 · Healthy Japanese adults aged 20 to under 75
3.2 mg/day undenatured type II collagen · 12 weeks
Knee flexion and range improved at weeks 4, 8 and 12 versus placebo, with improvements in JKOM, knee and back discomfort, walking and stair-climbing tests.
Row on the Type II Collagen (Undenatured) page · PubMed 35512781 (opens PubMed)
Grade CKnee extension and exercise-related knee discomfort in healthy adults · Improved
RCT · n 55 · 2013 · Healthy adults with knee discomfort after stepmill exercise but no arthritis
40 mg/day · 120 days
Knee extension improved versus placebo (81.0° vs 74.0°, P = 0.011), and the UC-II group exercised longer before discomfort began versus baseline. No product-related adverse events.
Row on the Type II Collagen (Undenatured) page · PubMed 24153020 (opens PubMed)