Thiamine (Vitamin B1) and heart failure

What 2 graded rows on thiamine (vitamin b1) agree on for heart failure, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Thiamine (Vitamin B1) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Thiamine (Vitamin B1) page, with its PubMed record.

Supplement

Thiamine (Vitamin B1) Choose another

2 rows · 572 people

They agree: both rows found no difference.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade C, is a meta-analysis of 298 people (2023) and found no difference.

The rows run from 274 to 298 people, published from 2023 to 2024: 2 pooled reviews and 0 single studies.

2 no difference

Grade CHeart failure: mortality, hospitalization and symptoms · No difference
Meta-analysis, 6 studies · n 298 · 2023 · Adults with symptomatic heart failure in 6 RCTs
Varied across trials (not given in the abstract) · Varied across trials
No significant differences in mortality (p=0.61), hospitalization (p=0.53), dyspnea, LVEF (p=0.08) or 6-minute walk; heart rate was the only outcome that changed (p=0.04).
Row on the Thiamine (Vitamin B1) page · PubMed 37126872 (opens PubMed)
Grade CHeart failure: ejection fraction, walking distance and NT-proBNP · No difference
Meta-analysis, 7 studies · n 274 · 2024 · Adults with chronic heart failure in 7 double-blind RCTs (5 parallel, 2 crossover)
Varied across trials (not given in the abstract) · Varied across trials
No significant effect versus placebo on LVEF (WMD 1.65%, 95% CI −1.10 to 4.41), end-diastolic volume, 6-minute walk, NT-proBNP or NYHA class. Thiamine did correct thiamine deficiency.
Row on the Thiamine (Vitamin B1) page · PubMed 38940395 (opens PubMed)