Thiamine (Vitamin B1) and diabetes complications
What 4 graded rows on thiamine (vitamin b1) agree on for diabetes complications, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Thiamine (Vitamin B1) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Thiamine (Vitamin B1) page, with its PubMed record.
Your question
Thiamine (Vitamin B1) and diabetes complications
4 rows · 312 peopleSplit. 1 row found an improvement, 2 found no difference and 1 had mixed results.
- CGrade C× 3
- DGrade D× 1
- Rows
- 4
- Trials
- 4
- People
- 312
Where they differ
From the rowsThe best-graded row, grade C, is a randomized trial of 133 people (2008) and reported mixed results.
The 2 rows that found no difference are newer (2010 to 2026) than the row that found an improvement (2009).
The best grade is C among the rows that found no difference, and D among the row that found an improvement.
1 row with mixed results is left out of this comparison.
The rows
1 improved · 2 no difference · 1 mixed- CGrade CUrinary albumin excretion in diabetic kidney disease · No difference
RCT · n 82 · 2010 · Adults with type 2 diabetes and albuminuria (15–300 mg/24 h) despite ACE inhibitors or ARBs (Netherlands)
900 mg/day · 12 weeks
Thiamine status improved (p<0.001), but neither 24-hour urinary albumin nor the kidney-injury marker KIM-1 fell versus placebo.
Row on the Thiamine (Vitamin B1) page · PubMed 20413516 (opens PubMed)
- CGrade CNerve structure, nerve function and symptoms in diabetic polyneuropathy · No difference
RCT · n 57 · 2026 · Adults with type 2 diabetes and mild-to-moderate symptomatic polyneuropathy (Germany, BOND study)
600 mg/day (300 mg twice daily) · 12 months
Corneal nerve fibre length (the primary outcome) did not change differently from placebo, and nerve conduction, sensory testing, autonomic tests, symptom scales and quality of life were also similar. Only the Neuropathy Symptom Score tended to improve (p=0.098). Blood thiamine levels rose; adverse events did not differ.
Row on the Thiamine (Vitamin B1) page · PubMed 41571333 (opens PubMed)
- DGrade DUrinary albumin excretion in type 2 diabetes · Improved
RCT · n 40 · 2009 · Adults with type 2 diabetes and microalbuminuria (Pakistan)
300 mg/day (3 × 100 mg) · 3 months
Urinary albumin fell from baseline with thiamine (median −17.7 mg/24 h) and was lower than placebo at 3 months (30.1 vs 35.5 mg/24 h, p<0.01).
Row on the Thiamine (Vitamin B1) page · PubMed 19057893 (opens PubMed)
- CGrade CDiabetic polyneuropathy symptoms · Mixed
RCT · n 133 · 2008 · Adults with symmetrical distal diabetic polyneuropathy (Germany)
300 or 600 mg/day · 6 weeks
The Neuropathy Symptom Score improved more with benfotiamine in the per-protocol analysis (p=0.033) but only borderline when all randomized patients were analysed (p=0.055); the Total Symptom Score did not differ. Effects were larger at 600 mg/day. Well tolerated.
Row on the Thiamine (Vitamin B1) page · PubMed 18473286 (opens PubMed)