Theacrine and energy

What 2 graded rows on theacrine agree on for energy, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Theacrine page, with its PubMed record.

Your question

Supplement
Theacrine Choose another

Theacrine and energy

2 rows · 34 people

Split. 1 row found an improvement and 1 found no difference.

No difference
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside.
  • Grade D× 2
Rows
2
Trials
2
People
34

Where they differ

From the rows
Who was studiedWhen published

The best-graded row, grade D, is a crossover trial of 19 people (2026) and found no difference.

Only the row that found no difference names women and men in its population.

The row that found no difference is newer (2026) than the row that found an improvement (2017).

The rows

1 improved · 1 no difference
  1. Grade DSelf-rated energy, fatigue and concentration · Improved

    Crossover RCT · n 15 · 2017 · Healthy adults

    200 mg, single dose · Single dose; ratings over 3 hours

    Energy, fatigue and concentration ratings improved versus placebo; resting heart rate, blood pressure, gas exchange and side-effect reports did not change.

    Row on the Theacrine page · PubMed 27164220 (opens PubMed)

  2. Grade DEnergy, cognition, heart rate and cortisol at high doses · No difference

    Crossover RCT · n 19 · 2026 · Healthy habitual caffeine users (14 women, 5 men)

    3, 6 or 9 mg per kg of body weight, single doses · One dose per visit, 7-day washout

    No effect on heart rate, blood pressure, self-rated energy, salivary alpha-amylase or cognitive performance; salivary cortisol was higher than with placebo at 120 and 180 minutes.

    Row on the Theacrine page · PubMed 41950524 (opens PubMed)

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