Sodium bicarbonate (baking soda) and kidney

What 2 graded rows on sodium bicarbonate (baking soda) agree on for kidney, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Sodium bicarbonate (baking soda) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Sodium bicarbonate (baking soda) page, with its PubMed record.

Your question

Exercise4 Kidney2

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Sodium bicarbonate (baking soda) and kidney

2 rows · 434 people

Split. 1 row found an improvement and 1 found no difference.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

Grade C× 1
No effect× 1

Rows: 2
Trials: 2
People: 434

Where they differ

From the rows

Trial sizeWho was studiedWhen published

The best-graded row, grade C, is a randomized trial of 134 people (2009) and found an improvement. 1 row is graded No effect, our grade for adequately powered trials that found no effect.

The row that found no difference was larger: 300 people, against 134 people for the row that found an improvement.

Only the row that found no difference names older adults in its population.

The row that found no difference is newer (2020) than the row that found an improvement (2009).

The rows

1 improved · 1 no difference

Grade CKidney function decline in advanced CKD with low bicarbonate · Improved
RCT · n 134 · 2009 · Adults with CKD (creatinine clearance 15–30) and serum bicarbonate 16–20 mmol/L
Oral sodium bicarbonate (dose not stated in the abstract) · 2 years
Creatinine clearance declined 1.88 vs 5.93 mL/min/1.73 m² per year; rapid progression 9% vs 45%; fewer reached end-stage kidney disease.
Row on the Sodium bicarbonate (baking soda) page · PubMed 19608703 (opens PubMed)
No effectPhysical function and kidney function in older adults with CKD · No difference
RCT · n 300 · 2020 · UK adults 60+ with eGFR <30 and serum bicarbonate <22 mmol/L
Up to 3 g/day · Up to 2 years
No effect on the Short Physical Performance Battery at 12 months (−0.4 points) or on GFR; adverse events were more frequent with bicarbonate (457 vs 400) and quality of life was lower.
Row on the Sodium bicarbonate (baking soda) page · PubMed 32268897 (opens PubMed)

Read onRead the full evidenceThe full evidence chapter on its page, with every outcome and its sources.