Rutin and vein swelling
What 2 graded rows on rutin agree on for vein swelling, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Rutin page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Rutin page, with its PubMed record.
Your question
Rutin and vein swelling
2 rows · 1,478 peopleSplit. 1 row found an improvement and 1 found no difference.
- CGrade C× 2
- Rows
- 2
- Trials
- 16
- People
- 1,478
- Pooled reviews may count some twice
Where they differ
From the rowsThe best-graded row, grade C, is a meta-analysis of 1,245 people (2020) and found an improvement.
The row that found an improvement was larger: 1,245 people, against 233 people for the row that found no difference.
The row that found an improvement is newer (2020) than the row that found no difference (2018).
The rows
1 improved · 1 no difference- CGrade CLeg swelling in chronic venous insufficiency (phlebotonic drugs, including rutosides) · Improved
Meta-analysis, 13 studies · n 1,245 · 2020 · Adults with chronic venous insufficiency (Cochrane review: 69 RCTs; 28 of the 56 analysable studies tested rutosides)
Varied by drug · Short-term trials
Phlebotonics as a group probably reduced lower-leg oedema slightly (RR 0.70; 13 studies, 1,245 participants) and ankle circumference, with little or no difference in quality of life and slightly more adverse events, mostly gastrointestinal, than placebo.
- CGrade CPost-thrombotic syndrome symptoms (rutosides) · No difference
Systematic review, 3 studies · n 233 · 2018 · People with post-thrombotic syndrome after deep vein thrombosis (Cochrane review, 3 studies)
Varied by study · Varied by study
No clear difference in improvement of post-thrombotic syndrome versus placebo or no treatment (OR 1.29; 2 studies, 164 participants) or versus compression stockings; evidence quality was low.