Rhapontic Rhubarb Extract (ERr 731) and menopause symptoms
What 3 graded rows on rhapontic rhubarb extract (err 731) agree on for menopause symptoms, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Rhapontic Rhubarb Extract (ERr 731) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Rhapontic Rhubarb Extract (ERr 731) page, with its PubMed record.
Your question
Rhapontic Rhubarb Extract (ERr 731) and menopause symptoms
3 rows · 611 peopleThey agree: all 3 rows found an improvement.
- BGrade B× 3
- Rows
- 3
- Trials
- 6
- People
- 611
- Pooled reviews may count some twice
What the rows share
From the rowsThe best-graded row, grade B, is a meta-analysis of 390 people (2024) and found an improvement.
The rows run from 109 to 390 people, published from 2006 to 2024: 1 pooled review and 2 single studies.
The rows
3 improved- BGrade BMenopause Rating Scale (pooled) · Improved
Meta-analysis, 4 studies · n 390 · 2024 · Perimenopausal women in 4 studies (193 ERr 731, 197 control)
Varied by study · Varied by study
MRS was 15.12 points lower with ERr 731 than control (p < 0.001); heterogeneity was high.
Row on the Rhapontic Rhubarb Extract (ERr 731) page · PubMed 38646867 (opens PubMed)
- BGrade BMenopause symptom score (confirmatory trial) · Improved
RCT · n 112 · 2009 · Perimenopausal women with menopausal symptoms
One tablet a day · 12 weeks
MRS total fell from 27.0 to 12.4 points vs 27.0 to 24.0 on placebo (p < 0.0001), with fewer hot flushes; 11 adverse events in 5 women on ERr 731 vs 3 in 3 on placebo.
Row on the Rhapontic Rhubarb Extract (ERr 731) page · PubMed 19161045 (opens PubMed)
- BGrade BMenopause symptom score and hot flushes · Improved
RCT · n 109 · 2006 · Perimenopausal women with climacteric complaints
One tablet a day · 12 weeks
The MRS II total score and each symptom fell more than with placebo (p < 0.0001), hot flush number and severity fell from week 4, and endometrial biopsies, bleeding and safety labs did not differ.
Row on the Rhapontic Rhubarb Extract (ERr 731) page · PubMed 16894335 (opens PubMed)