Red vine leaf extract (Vitis vinifera leaf) and chronic venous insufficiency
What 4 graded rows on red vine leaf extract (vitis vinifera leaf) agree on for chronic venous insufficiency, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Red vine leaf extract (Vitis vinifera leaf) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Red vine leaf extract (Vitis vinifera leaf) page, with its PubMed record.
Your question
Red vine leaf extract (Vitis vinifera leaf) and chronic venous insufficiency
4 rows · 641 peopleThey agree: all 4 rows found an improvement.
- BGrade B× 2
- CGrade C× 1
- DGrade D× 1
- Rows
- 4
- Trials
- 4
- People
- 641
What the rows share
From the rowsThe best-graded row, grade B, is a randomized trial of 257 people (2000) and found an improvement.
The rows run from 65 to 257 people, published from 2000 to 2011: 4 single studies.
The rows
4 improved- BGrade BLower-leg volume and symptoms in chronic venous insufficiency · Improved
RCT · n 257 · 2000 · Outpatients aged 25–75 with stage I to early stage II chronic venous insufficiency, not using compression stockings
360 mg or 720 mg once daily · 12 weeks
Lower-leg volume fell by 75.9 g (360 mg) and 99.9 g (720 mg) versus placebo; calf circumference and key symptoms also improved more (p<0.001). Adverse events were rare and usually mild.
Row on the Red vine leaf extract (Vitis vinifera leaf) page · PubMed 10719612 (opens PubMed)
- BGrade BLower-limb volume and leg pain · Improved
RCT · n 248 · 2011 · Adults with chronic venous insufficiency (CEAP C3–C4a) and moderate-to-severe symptoms
720 mg daily · 12 weeks
Limb volume fell by 19.9 ml more than placebo (p=0.027) and leg pain by 6.6 mm on a 10-cm scale (p=0.047); other symptoms did not change significantly. Tolerability was similar to placebo.
Row on the Red vine leaf extract (Vitis vinifera leaf) page · PubMed 21239190 (opens PubMed)
- CGrade CSkin microcirculation, oxygen supply and leg circumference · Improved
Crossover RCT · n 71 · 2004 · Adults with stage I–II chronic venous insufficiency
360 mg once daily · 6 weeks per period
Microvascular blood flow and transcutaneous oxygen rose versus placebo, and ankle and calf circumference fell (all p<0.0001).
Row on the Red vine leaf extract (Vitis vinifera leaf) page · PubMed 15293865 (opens PubMed)
- DGrade DLeg symptoms (tired, heavy legs, tension, tingling, pain) · Improved
Open-label trial · n 65 · 2003 · Adults aged 25–82 with grade I–II chronic venous insufficiency
360 mg once daily · 6 weeks
All subjective symptoms improved significantly from baseline; 6 people had adverse events possibly related to the extract, 4 of them gastrointestinal.
Row on the Red vine leaf extract (Vitis vinifera leaf) page · PubMed 12785119 (opens PubMed)