Pygeum and prostate

What 2 graded rows on pygeum agree on for prostate, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Pygeum page, with its PubMed record.

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Pygeum and prostate

2 rows · 1,771 people

They agree: both rows found an improvement.

No difference
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside.
  • Grade C× 1
  • Grade D× 1
Rows
2
Trials
19
People
1,771
Pooled reviews may count some twice

What the rows share

From the rows

The best-graded row, grade C, is a systematic review of 1,562 people (2002) and found an improvement.

The rows run from 209 to 1,562 people, published from 1999 to 2002: 1 pooled review and 1 single study.

The rows

2 improved
  1. Grade CUrinary symptoms and flow in benign prostatic hyperplasia · Improved

    Systematic review, 18 studies · n 1,562 · 2002 · Men with BPH symptoms in 18 RCTs

    Varied doses and preparations · Mean 64 days (range 30–122)

    Versus placebo, a moderately large improvement in combined symptom and flow measures (effect size −0.8 SD, 6 trials); men were twice as likely to report overall improvement (RR 2.1). Nighttime urination fell 19% and residual urine 24%, and peak flow rose 23%. Adverse effects were mild and similar to placebo.

    Row on the Pygeum page · PubMed 11869585 (opens PubMed)

  2. Grade DProstate symptom score (IPSS) and urine flow: once- versus twice-daily dosing · Improved

    RCT · n 209 · 1999 · Men with symptomatic BPH who completed the comparative phase

    50 mg twice daily or 100 mg once daily · 2 months randomized, then 10 months open-label at 100 mg/day

    Both schedules worked alike: IPSS improved 35–38% and peak flow rose 1.6–2.0 mL/s at 2 months. After 12 months IPSS fell from 16 to 9, and safety was similar across groups and phases.

    Row on the Pygeum page · PubMed 10475357 (opens PubMed)

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