Punicalagins (Pomegranate Ellagitannins) and heart markers
What 3 graded rows on punicalagins (pomegranate ellagitannins) agree on for heart markers, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Punicalagins (Pomegranate Ellagitannins) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Punicalagins (Pomegranate Ellagitannins) page, with its PubMed record.
Your question
Punicalagins (Pomegranate Ellagitannins) and heart markers
3 rows · 227 peopleThey agree: all 3 rows found an improvement.
- CGrade C× 1
- DGrade D× 2
- Rows
- 3
- Trials
- 3
- People
- 227
What the rows share
From the rowsThe best-graded row, grade C, is a randomized trial of 76 people (2025) and found an improvement.
The rows run from 67 to 84 people, published from 2019 to 2025: 3 single studies.
The rows
3 improved- CGrade CInflammatory markers and blood pressure in older adults · Improved
RCT · n 76 · 2025 · Adults aged 55 to 70
740 mg/day · 12 weeks
IL-6 and IL-1β fell with the extract (significant treatment-by-time interaction) and systolic pressure fell by 5.22 mmHg; CRP and TNF-α did not change significantly.
Row on the Punicalagins (Pomegranate Ellagitannins) page · PubMed 40218993 (opens PubMed)
- DGrade DEndothelial function, blood pressure and oxidised LDL (subgroups) · Improved
Crossover RCT · n 84 · 2019 · Middle-aged, apparently healthy adults (Madrid)
195 mg punicalagin + 9.9 mg hydroxytyrosol a day · 8 weeks per period
In people with endothelial dysfunction, flow-mediated dilation improved vs placebo (2.36 vs 0.76%); in those with high oxLDL, oxLDL fell vs placebo; prehypertensive and hypertensive participants had lower blood pressure (systolic -15.75 mmHg). Whole-group results are not reported in the abstract.
Row on the Punicalagins (Pomegranate Ellagitannins) page · PubMed 30884808 (opens PubMed)
- DGrade DBlood lipids (subgroups) · Improved
Crossover RCT · n 67 · 2022 · Adults aged 45 to 65 (84 randomized, 67 completed)
195 mg punicalagin + 9.9 mg hydroxytyrosol a day · 8 weeks per period
Triglycerides fell in people with high triglycerides (200.67 to 155.33 mg/dL), LDL fell in those with LDL of 160 mg/dL or more (179.13 to 162.93 mg/dL), and HDL rose in those with low HDL; placebo showed no such changes.
Row on the Punicalagins (Pomegranate Ellagitannins) page · PubMed 35565844 (opens PubMed)