Pregnenolone and craving and anxiety
What 3 graded rows on pregnenolone agree on for craving and anxiety, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Pregnenolone page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Pregnenolone page, with its PubMed record.
Your question
Pregnenolone and craving and anxiety
3 rows · 128 peopleThey agree: all 3 rows found an improvement.
- DGrade D× 3
- Rows
- 3
- Trials
- 3
- People
- 128
What the rows share
From the rowsThe best-graded row, grade D, is a pilot trial of 55 people (2025) and found an improvement.
The rows run from 30 to 55 people, published from 2022 to 2025: 3 single studies.
The rows
3 improved- DGrade DProvoked craving and cocaine use in cocaine use disorder · Improved
Pilot RCT · n 55 · 2025 · Treatment-seeking men and women with cocaine use disorder
300 or 500 mg/day · 8 weeks
Stress- and cue-induced craving rose with placebo but not with pregnenolone (p < .001). The 300 mg group used less cocaine than placebo (p = .047) and the 500 mg group; the drop in days of use was not significant (p = .122).
Row on the Pregnenolone page · PubMed 40570771 (opens PubMed)
- DGrade DStress- and cue-induced craving and anxiety in alcohol use disorder · Improved
RCT · n 43 · 2023 · Treatment-seeking adults with alcohol use disorder
300 or 500 mg/day · Laboratory testing in week 2 of an 8-week pilot trial
Both doses reduced stress- and alcohol cue-induced craving versus placebo; stress-induced anxiety fell only at 300 mg/day. Cortisol/ACTH responses were normalised.
Row on the Pregnenolone page · PubMed 36445398 (opens PubMed)
- DGrade DStress- and cue-induced craving and anxiety in cocaine use disorder · Improved
RCT · n 30 · 2022 · Treatment-seeking adults with cocaine use disorder
300 or 500 mg/day · 8 weeks (lab testing after 2 weeks)
Both doses reduced stress- and cue-induced craving; anxiety and stress-induced heart rate and blood pressure fell only at 500 mg/day.
Row on the Pregnenolone page · PubMed 36358943 (opens PubMed)