Omega-6 Fatty Acids and blood lipids

What 2 graded rows on omega-6 fatty acids agree on for blood lipids, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Omega-6 Fatty Acids page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Omega-6 Fatty Acids page, with its PubMed record.

Supplement

Omega-6 Fatty Acids Choose another

2 rows · 4,398 people

They agree: both rows found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade B, is a meta-analysis of 4,280 people (2018) and found an improvement.

The rows run from 118 to 4,280 people, published from 2018 to 2024: 1 pooled review and 1 single study.

2 improved

Grade BTotal cholesterol · Improved
Meta-analysis · n 4,280 · 2018 · Adults with or without cardiovascular disease (10 trials)
Varied across trials · At least 12 months
Total cholesterol fell by 0.33 mmol/L (high-quality evidence; heterogeneity partly explained by dose). Triglycerides, HDL and LDL showed little or no difference in fewer trials.
Row on the Omega-6 Fatty Acids page · PubMed 30488422 (opens PubMed)
Grade DLipoprotein(a) · Improved
RCT · n 118 · 2024 · Men homozygous for a FADS1 gene variant (Finland)
30 to 50 mL oil per day, by body size · 8 weeks
The linoleic acid diet lowered Lp(a) by 9.5% and the ALA diet by 7.3%, with no significant difference between diets; LDL cholesterol and apolipoprotein B fell more on the ALA diet.
Row on the Omega-6 Fatty Acids page · PubMed 38714425 (opens PubMed)