Methylcellulose and cholesterol

What 3 graded rows on methylcellulose agree on for cholesterol, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Methylcellulose page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Methylcellulose page, with its PubMed record.

Supplement

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3 rows · 225 people

They agree: all 3 rows found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade B, is a randomized trial of 160 people (1999) and found an improvement.

The rows run from 13 to 160 people, published from 1999 to 2009: 3 single studies.

3 improved

Grade BLDL cholesterol · Improved
RCT · n 160 · 1999 · Adults with mild to moderate high LDL cholesterol on a Step I diet
2.5, 5 or 7.5 g/day (vs placebo) · 6 weeks
LDL cholesterol fell by about 12% from baseline at 5 and 7.5 g/day, significantly more than placebo or 2.5 g/day. HDL, triglycerides and gastrointestinal adverse events did not differ between groups.
Row on the Methylcellulose page · PubMed 10569330 (opens PubMed)
Grade CTotal and LDL cholesterol · Improved
RCT · n 52 · 2009 · Adults with mildly high cholesterol (two trials: 12 and 40 participants)
5 or 15 g/day · 1 week per grade (trial 1); 8 weeks (trial 2)
In the 8-week trial, LDL cholesterol fell 8% at 5 g/day and 15% at 15 g/day more than placebo; higher-viscosity grades worked better in the 1-week trial. Adverse effects were described as minimal.
Row on the Methylcellulose page · PubMed 17882138 (opens PubMed)
Grade DLDL cholesterol on top of a statin · Improved
Crossover RCT · n 13 · 2009 · Men and women with high cholesterol on stable statin therapy (USA)
2.5 g twice daily (5 g/day) vs control · 4 weeks per period
LDL cholesterol fell 15.7% with HPMC versus 5.1% with control; total and non-HDL cholesterol and apo B also fell more. HDL and triglycerides did not differ.
Row on the Methylcellulose page · PubMed 19209184 (opens PubMed)