Manganese and joints
What 2 graded rows on manganese agree on for joints, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Manganese page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Manganese page, with its PubMed record.
Your question
Manganese and joints
2 rows · 127 peopleThey agree: both rows found an improvement.
- DGrade D× 2
- Rows
- 2
- Trials
- 2
- People
- 127
What the rows share
From the rowsThe best-graded row, grade D, is a randomized trial of 93 people (2000) and found an improvement.
The rows run from 34 to 93 people, published from 1999 to 2000: 2 single studies.
The rows
2 improved- DGrade DKnee osteoarthritis severity (Lequesne index) · Improved
RCT · n 93 · 2000 · Adults with knee osteoarthritis (US, single center)
Twice daily (304 mg/day manganese ascorbate) · 6 months
In mild to moderate osteoarthritis (72 people), severity scores improved versus placebo at 4 and 6 months (response 52% vs 28%); no benefit in severe osteoarthritis. Adverse events 17% vs 19% with placebo.
- DGrade DKnee and low back pain from degenerative joint disease · Improved
Crossover RCT · n 34 · 1999 · US Navy divers and special warfare personnel with chronic knee or low back pain
Glucosamine 1,500 mg, chondroitin 1,200 mg and manganese ascorbate 228 mg per day · 16 weeks (crossover)
Knee symptom scores, pain ratings and physical examination scores improved; running times did not change, and the study neither showed nor excluded a benefit for the spine.