Lion's mane mushroom and memory

What 3 graded rows on lion's mane mushroom agree on for memory, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Lion's mane mushroom page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Lion's mane mushroom page, with its PubMed record.

Supplement

Lion's mane mushroom Choose another

3 rows · 83 people

Mostly no difference: 2 of 3 rows, and most of the people. 1 found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

When published

The best-graded row, grade D, is a randomized trial of 41 people (2020) and found an improvement.

The 2 rows that found no difference are newer (2022 to 2025) than the row that found an improvement (2020).

1 improved · 2 no difference

Grade DCognition under fatigue and exercise fuel use · No difference
RCT · n 24 · 2022 · College-age adults
10 g/day · 4 weeks
No effect on dual-task cognition (Stroop plus mental arithmetic) or on fat and carbohydrate use during exercise versus placebo.
Row on the Lion's mane mushroom page · PubMed 36582308 (opens PubMed)
Grade DCognition and mood 90 minutes after one dose · No difference
Crossover RCT · n 18 · 2025 · Healthy adults aged 18–35
3 g once · Single dose, tested at 90 minutes
No effect on composite global cognition or mood versus placebo; one psychomotor task (pegboard) was faster after lion's mane.
Row on the Lion's mane mushroom page · PubMed 40276537 (opens PubMed)
Grade DCognitive and daily-function scores in mild Alzheimer's disease · Improved
RCT · n 41 · 2020 · Adults with mild Alzheimer's disease (Taiwan)
Three 350 mg capsules a day (1.05 g/day of mycelium) · 49 weeks
Cognitive screening (CASI) scores fell in the placebo group, MMSE scores rose in the mycelium group, and daily-activity (IADL) scores and contrast sensitivity differed in favour of the mycelium group. Four people dropped out with abdominal discomfort, nausea or skin rash.
Row on the Lion's mane mushroom page · PubMed 32581767 (opens PubMed)