Lion's mane mushroom and brain & focus

What 2 graded rows on lion's mane mushroom agree on for brain & focus, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Lion's mane mushroom page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Lion's mane mushroom page, with its PubMed record.

Supplement

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2 rows · 71 people

Split. 1 row found an improvement and 1 had mixed results.

Mixed

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.

From the rows

The best-graded row, grade D, is a pilot trial of 41 people (2023) and reported mixed results.

The rows run from 30 to 41 people, published from 2009 to 2023: 2 single studies.

1 improved · 1 mixed

Grade DCognitive function scores in older adults · Improved
RCT · n 30 · 2009 · Japanese adults aged 50–80 with mild cognitive impairment
Four 250 mg tablets three times a day (3 g/day) · 16 weeks, plus 4 weeks off
Cognitive scale scores rose significantly more than placebo at weeks 8, 12 and 16, then fell significantly 4 weeks after stopping. Laboratory tests showed no adverse effects.
Row on the Lion's mane mushroom page · PubMed 18844328 (opens PubMed)
Grade DCognition, stress and mood in healthy young adults · Mixed
Pilot RCT · n 41 · 2023 · Healthy adults aged 18–45
1.8 g (single amount and daily) · Single amount and 28 days
Participants were quicker on the Stroop task 60 minutes after a single amount, and subjective stress trended lower after 28 days (p = 0.051). Null and some negative findings were also observed.
Row on the Lion's mane mushroom page · PubMed 38004235 (opens PubMed)