Licorice root (Glycyrrhiza glabra) and blood pressure
What 3 graded rows on licorice root (glycyrrhiza glabra) agree on for blood pressure, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Licorice root (Glycyrrhiza glabra) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Licorice root (Glycyrrhiza glabra) page, with its PubMed record.
Your question
Licorice root (Glycyrrhiza glabra) and blood pressure
3 rows · 906 peopleThey agree: all 3 rows found a worse outcome.
- CGrade C× 3
- Rows
- 3
- Trials
- 27
- People
- 906
- Pooled reviews may count some twice
What the rows share
From the rowsThe best-graded row, grade C, is a meta-analysis of 541 people (2024) and found a worse outcome.
The rows run from 28 to 541 people, published from 2017 to 2024: 2 pooled reviews and 1 single study.
The rows
3 worse- CGrade CBlood pressure with glycyrrhizic acid vs licorice flavonoids · Worse
Meta-analysis, 8 studies · n 541 · 2024 · Adults in 8 randomized controlled trials of licorice or its components
Varied by trial · Varied by trial
Glycyrrhizic acid-dominant products raised systolic BP by 3.48 mmHg and diastolic BP by 1.27 mmHg; flavonoid-dominant products had no significant effect on either.
Row on the Licorice root (Glycyrrhiza glabra) page · PubMed 39519602 (opens PubMed)
- CGrade CBlood pressure, potassium, renin and aldosterone · Worse
Meta-analysis, 18 studies · n 337 · 2017 · Participants in 18 studies giving at least 100 mg glycyrrhizic acid a day
≥100 mg glycyrrhizic acid/day · Chronic intake (varied by study)
Systolic BP rose 5.45 mmHg and diastolic 3.19 mmHg; potassium fell 0.33 mmol/L and renin and aldosterone fell. Higher daily doses went with larger BP rises.
Row on the Licorice root (Glycyrrhiza glabra) page · PubMed 28660884 (opens PubMed)
- CGrade CHome blood pressure, renin and aldosterone · Worse
Crossover RCT · n 28 · 2024 · Healthy young adults (median age 24)
100 mg glycyrrhizic acid/day · 2 weeks per period
Home systolic BP +3.1 mmHg vs control (P = 0.018); renin −30% and aldosterone −45%; NT-proBNP rose in the most sensitive quartile.
Row on the Licorice root (Glycyrrhiza glabra) page · PubMed 38246526 (opens PubMed)