Lactobacillus helveticus and mood
What 6 graded rows on lactobacillus helveticus agree on for mood, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Lactobacillus helveticus page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Lactobacillus helveticus page, with its PubMed record.
Your question
Lactobacillus helveticus and mood
6 rows · 553 peopleSplit. 2 rows found an improvement, 2 found no difference and 2 had mixed results.
- CGrade C× 3
- DGrade D× 1
- ∅No effect× 2
- Rows
- 6
- Trials
- 6
- People
- 553
Where they differ
From the rowsThe best-graded row, grade C, is a randomized trial of 116 people (2024) and reported mixed results. 2 rows are graded No effect, our grade for adequately powered trials that found no effect.
By our six checks (size, design, length, who was studied, year and grade), the two sides do not differ cleanly. The dose and how each outcome was measured are in the rows below. 2 rows with mixed results are left out of this comparison.
The rows
2 improved · 2 no difference · 2 mixed- CGrade CDepression scores in major depressive disorder · Improved
RCT · n 110 · 2019 · Adults with major depressive disorder in Iran (81 completed)
Daily (dose not stated in the abstract) · 8 weeks
Beck Depression Inventory fell from 17.39 to 9.1 with the probiotic vs 18.18 to 15.55 on placebo (p = 0.042); a galactooligosaccharide prebiotic arm did not help.
Row on the Lactobacillus helveticus page · PubMed 29731182 (opens PubMed)
- CGrade CPsychological distress in healthy volunteers · Improved
RCT · n 55 · 2011 · Healthy adult volunteers in France
One stick a day (amount not stated in the abstract) · 30 days
HSCL-90 global severity, depression and anger scores and HADS global score improved vs placebo (P < 0.05); urinary free cortisol fell (P < 0.05).
Row on the Lactobacillus helveticus page · PubMed 20974015 (opens PubMed)
- ∅No effectWellbeing and anxiety in healthy adults · No difference
RCT · n 135 · 2023 · Healthy adults in Chile
Daily stick (dose not stated in the abstract) · 4 weeks
No significant effects in the whole sample; only people with healthy lifestyle scores showed better anxiety and emotional-regulation results in a modeling analysis.
Row on the Lactobacillus helveticus page · PubMed 37049546 (opens PubMed)
- ∅No effectMood, stress and anxiety in adults with low mood · No difference
RCT · n 79 · 2017 · Adults in New Zealand with at least moderate low mood, not on psychiatric drugs
Daily (dose not stated in the abstract) · 8 weeks
No difference from placebo on any psychological score (Cohen's d 0.07 to 0.16) or blood marker; responders were 23% vs 26% on placebo.
Row on the Lactobacillus helveticus page · PubMed 28068788 (opens PubMed)
- CGrade CDepression scores alongside usual treatment · Mixed
RCT · n 116 · 2024 · Adults with depression in Poland, many on antidepressants
Daily (dose not stated in the abstract) · 60 days
No advantage over placebo on the depression score (p = 0.45); more people reached a minimal clinically important improvement (74.5% vs 53.5%, p = 0.03).
Row on the Lactobacillus helveticus page · PubMed 38732635 (opens PubMed)
- DGrade DDepression and anxiety scores alongside antidepressants in older adults · Mixed
Pilot RCT · n 58 · 2026 · Adults aged 60 or older with moderate unipolar depression on standard antidepressant care, at two centres in India
Daily (amount not stated in the abstract) · 12 weeks, then 12 weeks of follow-up
Overall depression (MADRS) and anxiety (GAD-7) scores were lower in the probiotic group, but group-by-time interactions were not significant and quality of life improved equally in both groups.
Row on the Lactobacillus helveticus page · PubMed 42304935 (opens PubMed)