L-Serine and sleep
What 2 graded rows on l-serine agree on for sleep, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the L-Serine page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the L-Serine page, with its PubMed record.
Your question
L-Serine and sleep
2 rows · 213 peopleThey agree: both rows found an improvement.
- DGrade D× 2
- Rows
- 2
- Trials
- 2
- People
- 213
What the rows share
From the rowsThe best-graded row, grade D, is an open-label trial of 160 people (2023) and found an improvement.
The rows run from 53 to 160 people, published from 2014 to 2023: 2 single studies.
The rows
2 improved- DGrade DSleep problems with 300 mg/day (open comparison of four supplements) · Improved
Open-label trial · n 160 · 2023 · Adults with sleep problems
300 mg/day · One crossover period per supplement (length not stated in the abstract)
All four tested supplements (L-theanine, GABA, Apocynum venetum leaf extract and L-serine) were reported to improve sleep problems significantly; there was no placebo arm.
- DGrade DSelf-rated sleep quality with 3 g before bed · Improved
Crossover RCT · n 53 · 2014 · Healthy Japanese adults dissatisfied with their sleep
3 g, 30 minutes before bed · 4 nights per period (study 1); 2 nights (study 2, 9 people)
Sleep-initiation and sleep-maintenance ratings improved versus placebo in study 1; in study 2 two sleep-satisfaction ratings improved, and actigraph night waking showed only a trend (p=0.08).