L-Serine and rare genetic disorder
What 2 graded rows on l-serine agree on for rare genetic disorder, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the L-Serine page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the L-Serine page, with its PubMed record.
Your question
L-Serine and rare genetic disorder
2 rows · 28 peopleSplit. 1 row found an improvement and 1 had mixed results.
- DGrade D× 2
- Rows
- 2
- Trials
- 2
- People
- 28
What the rows share
From the rowsThe best-graded row, grade D, is an open-label trial of 24 people (2024) and found an improvement.
The rows run from 4 to 24 people, published from 2024 to 2025: 2 single studies.
The rows
1 improved · 1 mixed- DGrade DDevelopment and motor scores in children with GRIN loss-of-function variants · Improved
Open-label trial · n 24 · 2024 · Children aged 2–18 with GRIN gene loss-of-function variants (Spain-led study)
Not stated in the abstract · 52 weeks
Several adaptive-behaviour subdomains, gross motor function and quality of life improved from baseline, mostly in milder cases; one child stopped for irritability and insomnia. There was no control group.
- DGrade DDaily-task performance in children with GRIN2B variants (n-of-1 trials) · Mixed
RCT · n 4 · 2025 · Children with GRIN2B loss-of-function variants
Not stated in the abstract · 1 year (two 6-month cycles)
One task-performance measure improved at 1.5 months; most others moved in a favourable direction without reaching significance. Two of the four children appeared to benefit.