Inositol and pregnancy
What 3 graded rows on inositol agree on for pregnancy, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Inositol page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Inositol page, with its PubMed record.
Your question
Inositol and pregnancy
3 rows · 6,304 peopleThey agree: all 3 rows found an improvement.
- BGrade B× 1
- CGrade C× 2
- Rows
- 3
- Trials
- 20
- People
- 6,304
- Pooled reviews may count some twice
What the rows share
From the rowsThe best-graded row, grade B, is a meta-analysis of 4,765 people (2026) and found an improvement.
The rows run from 220 to 4,765 people, published from 2013 to 2026: 2 pooled reviews and 1 single study.
The rows
3 improved- BGrade BGestational diabetes incidence · Improved
Meta-analysis, 12 studies · n 4,765 · 2026 · Pregnant women, or women planning conception within 6 months, without pre-existing diabetes, in 12 RCTs
Varied across trials (not stated in the abstract) · During pregnancy or from preconception
Gestational diabetes was 44% less likely than with placebo or standard care. Hypertensive disorders, caesarean delivery, macrosomia, preterm birth and low newborn blood sugar did not differ.
- CGrade CGestational diabetes incidence · Improved
Systematic review, 7 studies · n 1,319 · 2023 · Pregnant women enrolled at 10–24 weeks in 7 RCTs (6 in Italy, 1 in Ireland)
Varied across trials · From enrolment to the glucose test or delivery
Gestational diabetes was less frequent with myo-inositol (RR 0.53, 95% CI 0.31–0.90; 6 studies, 1,140 women), rated low-certainty evidence. Hypertensive disorders (RR 0.34) and preterm birth (RR 0.35) were also lower.
- CGrade CGestational diabetes in women with a parent with type 2 diabetes · Improved
RCT · n 220 · 2013 · Pregnant women in Italy with a parent with type 2 diabetes
2,000 mg myo-inositol plus 200 mcg folic acid twice daily (4,000 mg/day); control got folic acid only · End of first trimester to delivery
Gestational diabetes occurred in 6% vs 15.3% (P = 0.04; odds ratio 0.35); fetal macrosomia was also less frequent. Other outcomes did not differ.