Hyaluronic Acid and skin
What 2 graded rows on hyaluronic acid agree on for skin, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Hyaluronic Acid page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Hyaluronic Acid page, with its PubMed record.
Your question
Hyaluronic Acid and skin
2 rows · 187 peopleThey agree: both rows found an improvement.
- BGrade B× 1
- CGrade C× 1
- Rows
- 2
- Trials
- 2
- People
- 187
What the rows share
From the rowsThe best-graded row, grade B, is a randomized trial of 147 people (2025) and found an improvement.
The rows run from 40 to 147 people, published from 2021 to 2025: 2 single studies.
The rows
2 improved- BGrade BSkin hydration, elasticity and wrinkle depth · Improved
RCT · n 147 · 2025 · Healthy Caucasian adults aged 18–60 (150 randomised, 147 in the primary analysis)
60 or 120 mg/day · 12 weeks
At 120 mg/day, skin hydration and elasticity rose and water loss through the skin, sebum and wrinkle depth around the eyes fell versus placebo, with thicker epidermis and denser dermis; 60 mg/day had similar but smaller effects. Skin colour, redness, pores and gloss did not change.
Row on the Hyaluronic Acid page · PubMed 41422283 (opens PubMed)
- CGrade CWrinkles, skin moisture and elasticity · Improved
RCT · n 40 · 2021 · Healthy Asian adults aged 35–64 (Taiwan)
120 mg/day · 12 weeks
Wrinkle scores, skin water content, water loss through the skin and elasticity all improved vs placebo by week 12, with gains already at week 8.
Row on the Hyaluronic Acid page · PubMed 34203487 (opens PubMed)