Hyaluronic Acid and joints

What 2 graded rows on hyaluronic acid agree on for joints, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Hyaluronic Acid page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Hyaluronic Acid page, with its PubMed record.

Supplement

Hyaluronic Acid Choose another

2 rows · 657 people

Split. 1 row found an improvement and 1 had mixed results.

Mixed

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.

From the rows

The best-graded row, grade D, is a systematic review of 597 people (2024) and found an improvement.

The rows run from 60 to 597 people, published from 2012 to 2024: 1 pooled review and 1 single study.

1 improved · 1 mixed

Grade DOsteoarthritis and low back pain symptoms · Improved
Systematic review, 11 studies · n 597 · 2024 · Adults aged 40–70 with osteoarthritis (10 studies) or low back pain (1 study)
30–300 mg/day · 4 weeks to 12 months
Nine of 11 studies reported better pain, WOMAC, function or stiffness scores; adverse effects were rare and mild.
Row on the Hyaluronic Acid page · PubMed 39886281 (opens PubMed)
Grade DKnee osteoarthritis symptoms · Mixed
RCT · n 60 · 2012 · Adults with knee osteoarthritis (Kellgren-Lawrence grade 2–3), Japan, all doing daily quadriceps exercise
200 mg/day · 12 months
Symptoms improved in both groups. The hyaluronan group did better only in the subgroup aged 70 or younger, and only at months 2 and 4.
Row on the Hyaluronic Acid page · PubMed 23226979 (opens PubMed)