Hesperidin and blood pressure
What 3 graded rows on hesperidin agree on for blood pressure, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Hesperidin page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Hesperidin page, with its PubMed record.
Your question
Hesperidin and blood pressure
3 rows · 839 peopleMostly an improvement: 2 of 3 rows, and most of the people. 1 had mixed results.
- CGrade C× 1
- DGrade D× 2
- Rows
- 3
- Trials
- 16
- People
- 839
- Pooled reviews may count some twice
What the rows share
From the rowsThe best-graded row, grade C, is a meta-analysis of 656 people (2024) and reported mixed results.
The rows run from 24 to 656 people, published from 2011 to 2024: 1 pooled review and 2 single studies.
The rows
2 improved · 1 mixed- DGrade DSystolic blood pressure and pulse pressure · Improved
RCT · n 159 · 2021 · Adults with pre- or stage-1 hypertension
500 mL/day · 12 weeks
Systolic blood pressure and pulse pressure fell in step with the drinks' hesperidin content over 12 weeks; enriched juice also lowered diastolic pressure.
- DGrade DDiastolic blood pressure · Improved
Crossover RCT · n 24 · 2011 · Healthy men aged 50–65 with overweight
Hesperidin amount matched to 500 mL orange juice (not stated in the abstract) · 4 weeks per period
Diastolic blood pressure was lower after orange juice or the hesperidin drink than after placebo; fasting microvascular reactivity did not change, but after-meal reactivity improved.
- CGrade CBlood pressure, by health status · Mixed
Meta-analysis, 14 studies · n 656 · 2024 · Healthy people and people with type 2 diabetes in 14 trials (Chinese and English literature)
Varied across trials · Varied across trials
No blood pressure effect overall or in healthy people (systolic −0.50, diastolic −0.51 mmHg, not significant). In type 2 diabetes, systolic pressure fell 4.32 mmHg (95% CI −7.77 to −0.87) and diastolic showed a non-significant trend (−3.72 mmHg).