Grape seed extract and blood pressure
What 4 graded rows on grape seed extract agree on for blood pressure, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Grape seed extract page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Grape seed extract page, with its PubMed record.
Your question
Grape seed extract and blood pressure
4 rows · 2,358 peopleSplit. 2 rows found an improvement, 1 found no difference and 1 had mixed results.
- CGrade C× 3
- DGrade D× 1
- Rows
- 4
- Trials
- 45
- People
- 2,358
- Pooled reviews may count some twice
Where they differ
From the rowsThe best-graded row, grade C, is a meta-analysis of 1,080 people (2022) and found an improvement.
The 2 rows that found an improvement were larger: a median of 945 people, against 78 people for the row that found no difference.
The 2 rows that found an improvement are pooled reviews of several trials; the row that found no difference is a single study.
The best grade is C among the rows that found an improvement, and D among the row that found no difference.
1 row with mixed results is left out of this comparison.
The rows
2 improved · 1 no difference · 1 mixed- CGrade CBlood pressure and heart rate (pooled controlled trials) · Improved
Meta-analysis, 19 studies · n 1,080 · 2022 · Adults in controlled trials
Varied; dose and duration shaped the effect · Varied
Diastolic pressure fell 2.20 mm Hg and heart rate 1.25 bpm; systolic pressure (−3.55 mm Hg) and flow-mediated dilation did not change significantly. Heterogeneity was high.
Row on the Grape seed extract page · PubMed 34798267 (opens PubMed)
- CGrade CSystolic and diastolic blood pressure (pooled RCTs) · Improved
Meta-analysis, 16 studies · n 810 · 2016 · Adults in randomized trials; larger effects in younger, obese or metabolic-syndrome groups
Varied across trials · Varied
Systolic pressure fell 6.08 mm Hg and diastolic 2.80 mm Hg; no sign of publication bias.
Row on the Grape seed extract page · PubMed 27537554 (opens PubMed)
- DGrade DBlood pressure in mildly raised blood pressure · No difference
RCT · n 78 · 2021 · Healthy adults aged 40-70 with mildly raised systolic pressure (125-140 mm Hg), no blood-pressure medicines (Germany); 80 randomised, 78 analysed (n from full text)
300 mg/day · 16 weeks
Systolic pressure fell 3.90 mm Hg on extract and 3.21 mm Hg on placebo, with no significant difference between groups (p = 0.72); subgroup analyses by sex showed only a trend toward benefit in men (p = 0.07). In a secondary outcome, perceived-stress worry scores fell more than on placebo (p = 0.025).
Row on the Grape seed extract page · PubMed 33671310 (opens PubMed)
- CGrade CBlood pressure, heart rate, lipids and CRP (early pooled RCTs) · Mixed
Meta-analysis, 9 studies · n 390 · 2011 · Adults in randomized trials
Varied across trials · Varied
Systolic pressure fell 1.54 mm Hg and heart rate 1.42 bpm; no effect on diastolic pressure, lipids or CRP.
Row on the Grape seed extract page · PubMed 21802563 (opens PubMed)