GlyNAC (Glycine + N-Acetylcysteine) and glutathione
What 2 graded rows on glynac (glycine + n-acetylcysteine) agree on for glutathione, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the GlyNAC (Glycine + N-Acetylcysteine) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the GlyNAC (Glycine + N-Acetylcysteine) page, with its PubMed record.
Your question
GlyNAC (Glycine + N-Acetylcysteine) and glutathione
2 rows · 130 peopleSplit. 1 row found an improvement and 1 found no difference.
- CGrade C× 1
- DGrade D× 1
- Rows
- 2
- Trials
- 2
- People
- 130
Where they differ
From the rowsThe best-graded row, grade C, is a randomized trial of 114 people (2022) and found no difference.
The row that found no difference was larger: 114 people, against 16 people for the row that found an improvement.
The row that found no difference is newer (2022) than the row that found an improvement (2011).
The best grade is C among the row that found no difference, and D among the row that found an improvement.
The rows
1 improved · 1 no difference- DGrade DGlutathione synthesis in older adults · Improved
Open-label trial · n 16 · 2011 · 8 older and 8 younger adults
Dose not stated in the abstract · 2 weeks
Supplementation raised red-cell glutathione concentration by 94.6% and its fractional synthesis rate by 78.8% in older adults, and lowered markers of oxidative stress to levels similar to younger adults.
Row on the GlyNAC (Glycine + N-Acetylcysteine) page · PubMed 21795440 (opens PubMed)
- CGrade CBlood glutathione in healthy older adults · No difference
RCT · n 114 · 2022 · Healthy older adults (mean age 65)
2.4, 4.8 or 7.2 g/day · 2 weeks
GlyNAC was safe and well tolerated but did not raise total glutathione (the primary endpoint) or the reduced-to-oxidized glutathione ratio compared with placebo; the abstract reports a post-hoc benefit only in a subgroup with higher oxidative stress or lower baseline glutathione.
Row on the GlyNAC (Glycine + N-Acetylcysteine) page · PubMed 35821844 (opens PubMed)