GlyNAC (Glycine + N-Acetylcysteine) and aging

What 2 graded rows on glynac (glycine + n-acetylcysteine) agree on for aging, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the GlyNAC (Glycine + N-Acetylcysteine) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the GlyNAC (Glycine + N-Acetylcysteine) page, with its PubMed record.

Supplement

GlyNAC (Glycine + N-Acetylcysteine) Choose another

2 rows · 52 people

They agree: both rows found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade C, is a pilot trial of 36 people (2023) and found an improvement.

The rows run from 16 to 36 people, published from 2021 to 2023: 2 single studies.

2 improved

Grade CGlutathione, oxidative stress and physical function in older adults · Improved
Pilot RCT · n 36 · 2023 · 24 older adults randomized (GlyNAC or alanine placebo) plus 12 young adults
Dose not stated in the abstract · 16 weeks (young adults 2 weeks)
GlyNAC, but not placebo, improved glutathione deficiency, oxidative stress, mitochondrial function, inflammation, insulin resistance, gait speed, strength, waist size and systolic blood pressure in older adults; it was safe and well tolerated.
Row on the GlyNAC (Glycine + N-Acetylcysteine) page · PubMed 35975308 (opens PubMed)
Grade DGlutathione, strength, gait speed and cognition · Improved
Open-label trial · n 16 · 2021 · 8 older adults and 8 young adults
Glycine 1.33 mmol/kg/day plus cysteine 0.81 mmol/kg/day given as NAC · 24 weeks, then 12 weeks off
In older adults GlyNAC corrected red-cell glutathione deficiency and lowered oxidative stress, with reported gains in strength, gait speed, cognition and body composition; benefits declined after stopping for 12 weeks.
Row on the GlyNAC (Glycine + N-Acetylcysteine) page · PubMed 33783984 (opens PubMed)