Exogenous Ketones and exercise

What 2 graded rows on exogenous ketones agree on for exercise, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Exogenous Ketones page, with its PubMed record.

Your question

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Exogenous Ketones and exercise

2 rows · 103 people

Split. 1 row found no difference and 1 found a worse outcome.

No difference or worse
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Red: a worse outcome.
  • Grade C× 1
  • Grade D× 1
Rows
2
Trials
9
People
103
Pooled reviews may count some twice

Where they differ

From the rows
Trial sizeStudy designWho was studiedWhen publishedGrade

The best-graded row, grade C, is a meta-analysis of 80 people (2022) and found no difference.

The row that found no difference was larger: 80 people, against 23 people for the row that found a worse outcome.

The row that found no difference is a pooled review of several trials; the row that found a worse outcome is a single study.

Only the row that found no difference names women and men in its population. Only the row that found a worse outcome names athletes or trained people in its population.

The row that found a worse outcome is newer (2023) than the row that found no difference (2022).

The best grade is C among the row that found no difference, and D among the row that found a worse outcome.

The rows

1 no difference · 1 worse
  1. Grade CEndurance exercise performance · No difference

    Meta-analysis, 8 studies · n 80 · 2022 · Participants in 8 RCTs (77 men, 3 women)

    Not stated in the abstract · Single doses before exercise

    No difference from control in endurance performance overall (Hedges g 0.136, 95% CI −0.195 to 0.467), in time to exhaustion or in time trials. Monoesters raised blood ketones more than precursors.

    Row on the Exogenous Ketones page · PubMed 35042186 (opens PubMed)

  2. Grade D20-minute cycling time-trial power · Worse

    Crossover RCT · n 23 · 2023 · Trained cyclists

    0.35 g/kg body weight, 30 minutes before exercise · Single dose

    Mean power was 2.4% lower after the ketone ester than after placebo (255 vs 261 W).

    Row on the Exogenous Ketones page · PubMed 37185454 (opens PubMed)

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