DMSO (dimethyl sulfoxide) and macular amyloidosis

What 2 graded rows on dmso (dimethyl sulfoxide) agree on for macular amyloidosis, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the DMSO (dimethyl sulfoxide) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the DMSO (dimethyl sulfoxide) page, with its PubMed record.

Supplement

DMSO (dimethyl sulfoxide) Choose another

2 rows · 38 people

Split. 1 row found an improvement and 1 found no difference.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

When published

The best-graded row, grade D, is an open-label trial of 20 people (2024) and found no difference.

The row that found no difference is newer (2024) than the row that found an improvement (2020).

1 improved · 1 no difference

Grade DPigmentation and itch in macular amyloidosis: DMSO vs tretinoin · Improved
RCT · n 18 · 2020 · Adults with bilateral primary macular amyloidosis (Iran)
Applied to the assigned side · Not stated in the abstract
Pigmentation fell faster on the DMSO side (difference in slopes −6.03, 95% CI −12.06 to −0.01; P = .049), and itch cleared on the DMSO side from the first follow-up visit.
Row on the DMSO (dimethyl sulfoxide) page · PubMed 32160368 (opens PubMed)
Grade DMacular amyloidosis: CO2 laser plus DMSO vs laser alone · No difference
Open-label trial · n 20 · 2024 · Patients with macular amyloidosis (Egypt)
DMSO after each monthly laser session · 4 sessions, assessed 3 months after the last
Pigmentation, itch and amyloid deposits fell on both sides, with no significant difference between laser plus DMSO and laser alone.
Row on the DMSO (dimethyl sulfoxide) page · PubMed 39400574 (opens PubMed)