DMSO (dimethyl sulfoxide) and chemotherapy extravasation

What 2 graded rows on dmso (dimethyl sulfoxide) agree on for chemotherapy extravasation, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the DMSO (dimethyl sulfoxide) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the DMSO (dimethyl sulfoxide) page, with its PubMed record.

Supplement

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2 rows · 147 people

They agree: both rows found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade D, is an open-label trial of 127 people (1995) and found an improvement.

The rows run from 20 to 127 people, published from 1988 to 1995: 2 single studies.

2 improved

Grade DSkin ulceration after chemotherapy extravasation · Improved
Open-label trial · n 127 · 1995 · Patients with extravasation of doxorubicin, epirubicin, mitomycin, mitoxantrone, cisplatin, carboplatin, ifosfamide or fluorouracil (Italy); 144 enrolled, 127 assessable
Every 8 hours over the extravasation site · 7 days (up to 6 weeks in some patients)
Only one patient developed an ulcer. Mild local burning and a characteristic breath odour were the only side effects.
Row on the DMSO (dimethyl sulfoxide) page · PubMed 7595748 (opens PubMed)
Grade DSkin ulceration after anthracycline extravasation · Improved
Open-label trial · n 20 · 1988 · Patients with anthracycline extravasation (USA); 16 observed for 3 months
Every 6 hours · 14 days, then 3 months of follow-up
No extravasation progressed to ulceration or needed surgery. Side effects were burning on application, itch, redness and mild scaling, blisters in 4 patients and breath odour in 6.
Row on the DMSO (dimethyl sulfoxide) page · PubMed 3183703 (opens PubMed)