DL-Phenylalanine and mood

What 2 graded rows on dl-phenylalanine agree on for mood, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the DL-Phenylalanine page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the DL-Phenylalanine page, with its PubMed record.

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2 rows · 50 people

Split. 1 row found an improvement and 1 had mixed results.

Mixed

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.

From the rows

The best-graded row, grade D, is a randomized trial of 27 people (1979) and reported mixed results.

The rows run from 23 to 27 people, published from 1975 to 1979: 2 single studies.

1 improved · 1 mixed

Grade DRemission of depression after failed antidepressants · Improved
Observational · n 23 · 1975 · Adults with depression that had not responded to standard antidepressants
50 or 100 mg/day · 15 days
The authors reported complete remission in 17 of 23 patients within 1 to 13 days and no important adverse reactions.
Row on the DL-Phenylalanine page · PubMed 1173765 (opens PubMed)
Grade DDepression scores vs the antidepressant imipramine · Mixed
RCT · n 27 · 1979 · Patients with depression
150 to 200 mg/day (vs imipramine) · 30 days
Hamilton depression and self-rated scores did not differ between DL-phenylalanine and imipramine; imipramine lowered anxiety more on days 10 and 20 and helped sleep more early on.
Row on the DL-Phenylalanine page · PubMed 387000 (opens PubMed)