DL-Phenylalanine and appetite
What 2 graded rows on dl-phenylalanine agree on for appetite, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the DL-Phenylalanine page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the DL-Phenylalanine page, with its PubMed record.
Your question
DL-Phenylalanine and appetite
2 rows · 43 peopleInconsistent: both rows reported mixed results.
- DGrade D× 2
- Rows
- 2
- Trials
- 2
- People
- 43
What the rows share
From the rowsThe best-graded row, grade D, is a crossover trial of 32 people (2020) and reported mixed results.
Each row reported mixed results on its own, so there is no side to compare. The rows enrolled 11 to 32 people and were published from 2020 to 2021.
The rows
2 mixed- DGrade DEnergy intake at a buffet meal and blood glucose after a drink · Mixed
Crossover RCT · n 32 · 2020 · Healthy lean young men (Australia), two parts of 16
5 or 10 g single dose (vs control) · Single doses on separate days
10 g, but not 5 g, raised the satiety hormone CCK, cut energy intake at the next meal and lowered blood glucose after a mixed drink. Neither dose changed gastric emptying.
Row on the DL-Phenylalanine page · PubMed 32560181 (opens PubMed)
- DGrade DAppetite, energy intake and gut hormones: L- vs D-phenylalanine · Mixed
Crossover RCT · n 11 · 2021 · Healthy volunteers, London (double-blind, placebo-controlled part)
10 g single dose of each form vs placebo · Single doses on separate days; meal served 70 minutes later
L-phenylalanine raised insulin, glucagon and GIP and lowered blood glucose after the meal vs placebo, but neither form changed hunger ratings or how much was eaten. D-phenylalanine raised the gut hormone PYY after the meal but not insulin or glucagon.
Row on the DL-Phenylalanine page · PubMed 32991046 (opens PubMed)