D-Serine and cognition
What 2 graded rows on d-serine agree on for cognition, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the D-Serine page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the D-Serine page, with its PubMed record.
Your question
D-Serine and cognition
2 rows · 85 peopleThey agree: both rows found an improvement.
- DGrade D× 2
- Rows
- 2
- Trials
- 2
- People
- 85
What the rows share
From the rowsThe best-graded row, grade D, is a crossover trial of 50 people (2016) and found an improvement.
The rows run from 35 to 50 people, published from 2015 to 2016: 2 single studies.
The rows
2 improved- DGrade DSpatial memory and problem solving (healthy older adults) · Improved
Crossover RCT · n 50 · 2016 · Healthy older adults (Brazil)
Not stated in the abstract · Not stated in the abstract (crossover with placebo)
Groton Maze learning test performance improved versus placebo, more so in people whose blood D-serine rose most; other cognitive tests and mood did not change.
- DGrade DMood, attention and verbal memory after one dose (healthy young adults) · Improved
Crossover RCT · n 35 · 2015 · Healthy adults aged 23–29 (Israel)
2.1 g single dose · Single dose per session (crossover with placebo)
Self-rated sadness and anxiety were lower, attention (CPT-IP) improved and one verbal-memory measure improved versus placebo; the dose was well tolerated.