Comfrey and joints

What 2 graded rows on comfrey agree on for joints, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Comfrey page, with its PubMed record.

Your question

Comfrey and joints

2 rows · 263 people

They agree: both rows found an improvement.

No difference
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside.
  • Grade B× 1
  • Grade C× 1
Rows
2
Trials
2
People
263

What the rows share

From the rows

The best-graded row, grade B, is a randomized trial of 220 people (2007) and found an improvement.

The rows run from 43 to 220 people, published from 2007 to 2011: 2 single studies.

The rows

2 improved
  1. Grade BPainful knee osteoarthritis (vs placebo) · Improved

    RCT · n 220 · 2007 · Adults with painful knee osteoarthritis (153 women, 67 men; mean age 57.9; symptoms for 6.5 years)

    6 g a day (2 g three times a day) · 3 weeks

    The pain score (VAS total) fell by 51.6 mm (54.7%) with comfrey vs 10.1 mm (10.7%) with placebo, a difference of 41.5 mm (95% CI 34.8 to 48.2). WOMAC scores, knee mobility and quality of life also improved more.

    Row on the Comfrey page · PubMed 17169543 (opens PubMed)

  2. Grade CKnee osteoarthritis pain, stiffness and function (blend creams) · Improved

    RCT · n 43 · 2011 · Men and women aged 45 to 83 with primary knee osteoarthritis

    Three times a day · 6 weeks

    Both comfrey creams beat the reference cream for WOMAC pain, stiffness and daily function (all P < .01). Two people in each active group had temporary rash and itching.

    Row on the Comfrey page · PubMed 22014903 (opens PubMed)

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