Clostridium butyricum and antibiotic side effects

What 2 graded rows on clostridium butyricum agree on for antibiotic side effects, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Clostridium butyricum page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Clostridium butyricum page, with its PubMed record.

Supplement

Clostridium butyricum Choose another

2 rows · 407 people

They agree: both rows found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade D, is a randomized trial of 372 people (2012) and found an improvement.

The rows run from 35 to 372 people, published from 2005 to 2012: 2 single studies.

2 improved

Grade DAntibiotic-associated diarrhea in young children (with Bifidobacterium) · Improved
RCT · n 372 · 2012 · Children aged 3 months to 3 years hospitalized with pneumonia (China, multicenter)
5 × 10⁹ CFU/day · 7 days with antibiotics
Antibiotic-associated diarrhea occurred in 7.8% vs 16.8% of controls (relative risk 0.42); no drug-related adverse reactions.
Row on the Clostridium butyricum page · PubMed 23302558 (opens PubMed)
Grade DGut flora and GI side effects during H. pylori triple therapy (CBM588) · Improved
RCT · n 35 · 2005 · Adults with H. pylori-positive gastric or duodenal ulcers
Not stated in the abstract (started 7 days before antibiotics) · About 2 weeks
Anaerobic gut bacteria did not fall as they did without CBM588, and abdominal symptoms were less frequent.
Row on the Clostridium butyricum page · PubMed 16437727 (opens PubMed)