Cissus quadrangularis and weight
What 5 graded rows on cissus quadrangularis agree on for weight, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Cissus quadrangularis page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Cissus quadrangularis page, with its PubMed record.
Your question
Cissus quadrangularis and weight
5 rows · 540 peopleMostly an improvement: 4 of 5 rows, and most of the people. 1 found no difference.
- CGrade C× 1
- DGrade D× 4
- Rows
- 5
- Trials
- 5
- People
- 540
Where they differ
From the rowsThe best-graded row, grade C, is a randomized trial of 248 people (2025) and found an improvement.
The 4 rows that found an improvement were larger: a median of 98 people, against 30 people for the row that found no difference.
The best grade is C among the rows that found an improvement, and D among the row that found no difference.
The rows
4 improved · 1 no difference- CGrade CBody weight and body fat · Improved
RCT · n 248 · 2025 · Adults with overweight or obesity (BMI 25–34.9)
300 mg once daily · 16 weeks
Compared with placebo, the Cissus group lost 5.8% of body weight and 10.9% of body fat, with higher GLP-1 and lower DPP-4 activity; the authors describe the responses as comparable to semaglutide.
Row on the Cissus quadrangularis page · PubMed 41597327 (opens PubMed)
- DGrade DBody weight and metabolic syndrome markers · Improved
RCT · n 123 · 2006 · Adults with overweight or obesity, with or without a calorie-controlled diet
514 mg twice daily (from the full text; not in the abstract) · 8 weeks
The formulation groups had net reductions in weight, central obesity, fasting glucose, total and LDL cholesterol, triglycerides and C-reactive protein compared with placebo, with or without dieting.
Row on the Cissus quadrangularis page · PubMed 16948861 (opens PubMed)
- DGrade DBody weight, body fat and waist size · Improved
RCT · n 72 · 2008 · Adults with overweight or obesity
150 mg Cissus twice daily, or 250 mg Cissus–Irvingia twice daily (from the full text; not in the abstract) · 10 weeks
Both active groups lost more weight, body fat and waist size than placebo by week 10, with larger losses for the Cissus–Irvingia combination.
Row on the Cissus quadrangularis page · PubMed 18377661 (opens PubMed)
- DGrade DBody fat measured by DEXA scan · Improved
Pilot RCT · n 67 · 2019 · Adults with overweight and metabolic syndrome features who kept their usual diet and exercise
300 mg daily · 8 weeks
Body fat fell 12.8% by DEXA with the extract versus no change with placebo; waist, blood pressure, cholesterol, triglycerides and fasting glucose also fell compared with placebo.
Row on the Cissus quadrangularis page · PubMed 29912570 (opens PubMed)
- DGrade DWaist and hip size (independent trial) · No difference
RCT · n 30 · 2021 · Thai adults with obesity (BMI 25 or more) who kept their usual diet and activity
300 mg twice daily (600 mg/day, from the full text) · 8 weeks
Waist size fell from baseline at weeks 4 and 8 and hip size at week 8 in the Cissus group, but the full text reports no treatment or treatment-by-time effect versus placebo. Liver and kidney tests stayed in the normal range.
Row on the Cissus quadrangularis page · PubMed 33479386 (opens PubMed)