Cissus quadrangularis and bone

What 2 graded rows on cissus quadrangularis agree on for bone, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Cissus quadrangularis page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Cissus quadrangularis page, with its PubMed record.

Supplement

Cissus quadrangularis Choose another

2 rows · 488 people

Split. 1 row found no difference and 1 had mixed results.

No difference or mixed

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.

From the rows

The best-graded row, grade C, is a randomized trial of 134 people (2022) and found no difference.

The rows run from 134 to 354 people, published from 2022 to 2025: 1 pooled review and 1 single study.

1 no difference · 1 mixed

Grade CBone mineral density · No difference
RCT · n 134 · 2022 · Postmenopausal women with osteopenia
1.2 g or 1.6 g per day · 24 weeks
Bone density changes did not differ from placebo at any site; a bone-formation marker (P1NP) fell compared with placebo, and side effects were similar across groups. 108 of 134 women completed the study.
Row on the Cissus quadrangularis page · PubMed 35523116 (opens PubMed)
Grade DBlood markers of bone metabolism · Mixed
Meta-analysis, 7 studies · n 354 · 2025 · Seven human trials
Varied across trials · Varied across trials
Cissus raised parathyroid hormone levels but did not change calcium, phosphorus or alkaline phosphatase; certainty of evidence was very low for all four measures.
Row on the Cissus quadrangularis page · PubMed 40707943 (opens PubMed)