Bacillus subtilis and antibiotic diarrhea

What 2 graded rows on bacillus subtilis agree on for antibiotic diarrhea, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Bacillus subtilis page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Bacillus subtilis page, with its PubMed record.

Supplement

Bacillus subtilis Choose another

2 rows · 5,768 people

They agree: both rows found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade C, is a meta-analysis of 5,700 people (2026) and found an improvement.

The rows run from 68 to 5,700 people, published from 2025 to 2026: 1 pooled review and 1 single study.

2 improved

Grade CAntibiotic-associated diarrhea (two-strain product) · Improved
Meta-analysis, 33 studies · n 5,700 · 2026 · Children and adults on antibiotics in 33 trials (2,919 on the product, 2,781 controls)
Varied across trials · Varied across trials
Added to symptomatic care, the product raised the treatment response rate (OR 6.54) and shortened symptoms by 1.8 days, and lowered the incidence of diarrhea when used to head it off (OR 0.275), vs symptomatic care alone.
Row on the Bacillus subtilis page · PubMed 41125358 (opens PubMed)
Grade CAntibiotic-associated diarrhea in children · Improved
RCT · n 68 · 2025 · Children aged 1 to 12 in India with diarrhea after antibiotics
2 billion CFU a day · 7 days
By day 3, 93.5% on HU58 had normal stools vs 22.6% on placebo (P < 0.001); almost all children in both groups were normal by day 7. Abdominal pain fell more with HU58.
Row on the Bacillus subtilis page · PubMed 40716758 (opens PubMed)