Artichoke Extract and cholesterol

What 3 graded rows on artichoke extract agree on for cholesterol, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Artichoke Extract page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Artichoke Extract page, with its PubMed record.

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3 rows · 1,039 people

Mostly an improvement: 2 of 3 rows, and most of the people. 1 had mixed results.

Mixed

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.

From the rows

The best-graded row, grade C, is a meta-analysis of 702 people (2018) and found an improvement.

The rows run from 75 to 702 people, published from 2008 to 2018: 2 pooled reviews and 1 single study.

2 improved · 1 mixed

Grade CTotal cholesterol, LDL, HDL and triglycerides · Improved
Meta-analysis, 9 studies · n 702 · 2018 · Adults in 9 RCTs
Varied across trials · Varied across trials
Total cholesterol fell 17.6 mg/dL, LDL 14.9 mg/dL and triglycerides 9.2 mg/dL versus control; HDL did not change. LDL fell more in people with higher starting LDL.
Row on the Artichoke Extract page · PubMed 28609140 (opens PubMed)
Grade CPlasma lipids in mild to moderate high cholesterol · Improved
RCT · n 75 · 2008 · Otherwise healthy adults with total cholesterol 6.0–8.0 mmol/L
1,280 mg/day · 12 weeks
Total cholesterol fell 4.2% versus a 1.9% rise on placebo (p=0.025); LDL, HDL and triglycerides did not differ between groups.
Row on the Artichoke Extract page · PubMed 18424099 (opens PubMed)
Grade CCholesterol in people with high cholesterol · Mixed
Systematic review, 3 studies · n 262 · 2013 · Adults with hypercholesterolaemia in 3 RCTs
Varied across trials · 6 to 12 weeks
Two trials found significant total-cholesterol reductions (4.2% and 18.5% versus 1.9% rise and 8.6% fall on placebo); the reviewers judged the evidence promising but not convincing. Adverse events were mild, transient and infrequent.
Row on the Artichoke Extract page · PubMed 23543518 (opens PubMed)