Arnica and muscle soreness

What 4 graded rows on arnica agree on for muscle soreness, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Arnica page, with its PubMed record.

Your question

Arnica and muscle soreness

4 rows · 555 people

Split. 1 row found an improvement, 1 found no difference, 1 found a worse outcome and 1 had mixed results.

No difference, mixed or worse
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Red: a worse outcome. Outlined: mixed results.
  • Grade C× 1
  • Grade D× 2
  • No effect× 1
Rows
4
Trials
5
People
555
Pooled reviews may count some twice

Where they differ

From the rows
Trial sizeStudy designHow longWhen published

The best-graded row, grade C, is a meta-analysis of 82 people (2003) and found an improvement. 1 row is graded No effect, our grade for adequately powered trials that found no effect.

The row that found no difference was larger: 400 people, against 82 people for the row that found an improvement.

The row that found an improvement is a pooled review of several trials; the row that found no difference is a single study.

The row that found no difference ran longer (5 days) than the row that found an improvement (3 days).

The row that found an improvement is newer (2003) than the row that found no difference (1998).

1 row with mixed results is left out of this comparison.

The rows

1 improved · 1 no difference · 1 worse · 1 mixed
  1. Grade CMuscle soreness after a marathon (homeopathic D30, pooled) · Improved

    Meta-analysis, 2 studies · n 82 · 2003 · Marathon runners from two randomized placebo-controlled trials (Oslo Marathon 1990 and 1995)

    Five pills morning and evening · From the evening before the race to 3 days after

    Soreness right after the marathon was lower with arnica (P = 0.04); muscle enzymes, a measure of cell damage, did not differ.

    Row on the Arnica page · PubMed 14587684 (opens PubMed)

  2. No effectMuscle soreness after long-distance running (homeopathic 30x) · No difference

    RCT · n 400 · 1998 · Runners expecting delayed-onset soreness after long-distance races (519 randomized)

    As directed in the trial for 5 days · 5 days after the race

    Mean 2-day soreness scores were 45.2 mm with arnica and 41.0 mm with placebo (95% CI 8.81 mm favouring placebo to 0.51 mm favouring arnica); race times did not differ.

    Row on the Arnica page · PubMed 9758072 (opens PubMed)

  3. Grade DLeg pain after calf-raise exercise (topical cream) · Worse

    RCT · n 53 · 2010 · 53 subjects doing a standard calf-raise protocol, one leg arnica and one leg placebo

    Applied right after exercise and at 24 and 48 hours · 4 days

    Pain scores 24 hours after exercise were higher on arnica-treated legs than on placebo legs (3.04 vs 2.36, p < 0.005); there was no difference at days 3 and 4, and muscle tenderness and ankle range of motion did not differ.

    Row on the Arnica page · PubMed 20807867 (opens PubMed)

  4. Grade DMuscle soreness and recovery after downhill running (topical) · Mixed

    RCT · n 20 · 2014 · Well-trained men with delayed-onset muscle soreness

    Every 4 waking hours · 96 hours

    The arnica group reported less pain and muscle tenderness 72 hours after the run. Arnica did not change strength or jump performance, or blood markers of muscle damage and inflammation.

    Row on the Arnica page · PubMed 23947690 (opens PubMed)

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