Apigenin and sleep
What 4 graded rows on apigenin agree on for sleep, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Apigenin page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Apigenin page, with its PubMed record.
Your question
Apigenin and sleep
4 rows · 969 peopleSplit. 2 rows found an improvement and 2 found no difference.
- CGrade C× 1
- DGrade D× 3
- Rows
- 4
- Trials
- 13
- People
- 969
- Pooled reviews may count some twice
Where they differ
From the rowsThe best-graded row, grade C, is a meta-analysis of 772 people (2024) and found an improvement.
The 2 rows that found an improvement were larger: a median of 416 people, against a median of 69 people for the 2 rows that found no difference.
Only the 2 rows that found an improvement include pooled reviews of several trials (1 of 2); the 2 rows that found no difference are single studies.
Only the 2 rows that found an improvement name older adults in their population.
The best grade is C among the rows that found an improvement, and D among the rows that found no difference.
The rows
2 improved · 2 no difference- CGrade CSleep quality (PSQI) with chamomile · Improved
Meta-analysis, 10 studies · n 772 · 2024 · Healthy and unwell adults in 10 chamomile trials; sleep-quality scores pooled from 5
Varied by trial · Varied by trial
Pittsburgh Sleep Quality Index scores fell (WMD -1.88, 95% CI -3.46 to -0.31; high heterogeneity). Night awakenings improved in two of three trials, but sleep duration, sleep efficiency and daytime function did not improve.
- DGrade DSleep quality in older adults (chamomile extract) · Improved
RCT · n 60 · 2017 · Adults aged 60+ in a day-care nursing home (Iran)
200 mg twice daily · 28 days
Pittsburgh Sleep Quality Index scores were better than with a wheat-flour placebo after the intervention (P<0.05).
- DGrade DStress and sleep (evening blend with 50 mg apigenin) · No difference
RCT · n 103 · 2026 · Healthy, physically active adults
Evening dose of the blend · 2 weeks
The evening blend showed no reported sleep or stress benefit over placebo; the improvements went to the morning ashwagandha and rhodiola group.
- DGrade DSleep diary measures in chronic insomnia (chamomile extract) · No difference
Pilot RCT · n 34 · 2011 · Adults aged 18–65 with chronic primary insomnia (USA)
270 mg chamomile extract twice daily · 28 days
No significant differences from placebo in total sleep time, sleep efficiency, sleep latency, night waking or sleep quality. Daytime functioning showed a modest, non-significant advantage.