Alpha-Galactosidase and gas

What 3 graded rows on alpha-galactosidase agree on for gas, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Alpha-Galactosidase page, with its PubMed record.

Your question

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Alpha-Galactosidase and gas

3 rows · 79 people

They agree: all 3 rows found an improvement.

No difference
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside.
  • Grade C× 1
  • Grade D× 2
Rows
3
Trials
3
People
79

What the rows share

From the rows

The best-graded row, grade C, is a randomized trial of 52 people (2013) and found an improvement.

The rows run from 8 to 52 people, published from 1994 to 2013: 3 single studies.

The rows

3 improved
  1. Grade CGas-related symptoms in children · Improved

    RCT · n 52 · 2013 · Children aged 4 to 17 with chronic or recurrent gas-related symptoms (27 enzyme, 25 placebo)

    Dosed by body weight (amount not stated in the abstract) · 2 weeks

    Global distress fell more than with placebo (p = 0.02), with fewer days of moderate to severe bloating (p = 0.03) and fewer children with flatulence (p = 0.02); abdominal spasms and distension did not differ. No adverse events were reported.

    Row on the Alpha-Galactosidase page · PubMed 24063420 (opens PubMed)

  2. Grade DFlatulence after a bean chili meal · Improved

    Crossover RCT · n 19 · 1994 · 19 volunteers

    8 drops with the meal (vs placebo) · Two test meals one week apart, 6-hour follow-up

    Flatulence events per hour were lower than placebo over 6 hours (p = .016), significant at hour 5 only; bloating and pain did not differ.

    Row on the Alpha-Galactosidase page · PubMed 7964541 (opens PubMed)

  3. Grade DGas production and flatulence after a bean meal · Improved

    RCT · n 8 · 2007 · Healthy volunteers

    300 or 1,200 GalU with a meal of 420 g cooked beans (vs placebo) · Single test meals, 8-hour follow-up

    1,200 GalU significantly reduced breath hydrogen and the severity of flatulence; both 300 and 1,200 GalU reduced the total symptom score.

    Row on the Alpha-Galactosidase page · PubMed 17151807 (opens PubMed)

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