Alanylglutamine and gut barrier

What 3 graded rows on alanylglutamine agree on for gut barrier, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Alanylglutamine page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Alanylglutamine page, with its PubMed record.

Supplement

Alanylglutamine Choose another

3 rows · 293 people

They agree: all 3 rows found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade C, is a randomized trial of 140 people (2020) and found an improvement.

The rows run from 46 to 140 people, published from 2007 to 2020: 3 single studies.

3 improved

Grade CGut permeability and growth in undernourished children · Improved
RCT · n 140 · 2020 · Children aged 2–60 months at risk of environmental enteropathy (Fortaleza, Brazil)
3, 6 or 12 g/day · 10 days, follow-up to 120 days
At the highest dose, urinary lactulose excretion improved modestly (0.19% to 0.17%, p = 0.05). Weight-for-height improved transiently in two groups at day 10 and weight measures in all groups at day 30. No effect on diarrhoea or fecal inflammation markers.
Row on the Alanylglutamine page · PubMed 32826717 (opens PubMed)
Grade CIntestinal permeability and weight gain in children with poor growth · Improved
RCT · n 107 · 2007 · Children aged about 8 months to 7 years with low weight or height z-scores (northeastern Brazil)
24 g/day · 10 days, follow-up to 120 days
Lactulose excretion improved with alanyl-glutamine but not with glycine, and weight-for-height and weight-for-age gains over 120 days were greater. Height-for-age did not change.
Row on the Alanylglutamine page · PubMed 17325559 (opens PubMed)
Grade DIntestinal absorption in people with HIV/AIDS · Improved
RCT · n 46 · 2013 · 46 adults with HIV/AIDS in Brazil
24 g/day (placebo glycine 25 g/day) · 10 days
Urinary mannitol excretion, a marker of absorption, rose in the alanyl-glutamine group (median 14.38% to 21.24%, n = 14, P = 0.0382); recent diarrhoea was linked to worse permeability at baseline.
Row on the Alanylglutamine page · PubMed 23657308 (opens PubMed)