Taxifolin
Summary
Taxifolin, also called dihydroquercetin, is a flavonoid from larch wood. Human evidence is very thin: one crossover trial in 28 students found a single serving of a taxifolin-rich larch food improved calculation tasks and eased mental fatigue during testing (grade D). A 12-week trial in mild cognitive impairment has been designed but has not reported.
Key facts
- A flavonoid (dihydroquercetin) found in onion, milk thistle, French maritime pine bark and Douglas fir bark; supplements are usually larch-wood extracts[2][4]
- One published randomized crossover trial: 28 healthy students, a single serving of about 107 mg taxifolin[1][4]
- Calculation-task performance improved and self-rated mental fatigue fell versus placebo over repeated test sets[1]
- A 60-person crossover trial of 100 mg a day for 12 weeks in mild cognitive impairment or mild dementia has published its protocol, not results[3]
- 1 graded human outcome on this page
- October 11, 2026
How it works
ProposedLab and animal studies describe antioxidant and anti-inflammatory effects, and inhibition of amyloid-β aggregation. None of these has been shown to translate into a health outcome in people.[2][3]
What the human research says
Human trials only, one row per outcome. The form column shows what each trial actually tested. Grades follow our evidence-grading policy.
| Outcome | Effect | Grade | Best evidence | PMID |
|---|---|---|---|---|
| Mental calculation and mental fatigue after a single serving | Improved | Grade D | Crossover RCT · n = 28 · 2023 Healthy university students aged 20–29 Form: Dahurian larch extract in food tablets (placebo tablets matched, including 300 mg vitamin C) · Dose: Single serving of about 107 mg taxifolin (six tablets containing 120 mg larch extract) · Duration: Single dose, tested over 4 repeated task sets Calculation-task performance improved and subjective mental fatigue was lower than with placebo. | 36946764 (opens PubMed)Source [1] |
Forms
| Form | Elemental % | Absorption (human data) | GI tolerance | Studied for |
|---|---|---|---|---|
| Dahurian larch wood extract standardized to dihydroquercetin | Varies[2] | No human absorption data in our sources.[2] | No adverse effects reported in the abstract of the single-dose trial; long-term tolerance is untested in published trials.[1] | Mental fatigue (single dose) |
Studied doses
Doses studied in human trials ranged from a single serving of about 107 mg of taxifolin in the only published randomized trial; daily use over weeks has not yet been reported.[1][4]
Interactions
Published interactions only: each row cites a source. No row means none was found in our sources, not that a combination is safe.
None found in our sources.
Who should be careful
Talk to your pharmacist or clinician before starting a supplement, especially if you take prescription medicines.
Where to buy Taxifolin
Products from brands we partner with that contain Taxifolin. Listing a product is not a claim that it works; check the amount per serving against the doses studied above, and the label for other ingredients.
- SupersmartPaid linkTaxifolin6 tablets: 60 mg dihydroquercetin (from 66 mg Dahurian larch extract standardized to 90%); 16 servings per 100 tablets. Below the single 107 mg serving tested in the one published trial; daily use has not been tested, and the registered dementia trial plans 100 mg a day.Shop at Supersmart (opens in new tab)Price and label checked 2026-10-11 on the brand’s site.
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Frequently asked questions
Is taxifolin the same as quercetin?
No. Taxifolin is dihydroquercetin, a closely related flavonoid that is studied separately. It is also present in milk thistle extract and Pycnogenol.[2]
Does taxifolin improve memory?
Not shown in people. A single serving improved calculation tasks and mental fatigue in students; memory claims come from animal studies.[1][2]
Sources
- [1]Ingestion of taxifolin-rich foods affects brain activity, mental fatigue, and the whole blood transcriptome in healthy young adults: a randomized, double-blind, placebo-controlled, crossover study.. Food Funct, 2023. crossover-RCT
- [2]An insight into the health-promoting effects of taxifolin (dihydroquercetin).. Phytochemistry, 2019. review
- [3]Taxifolin for prevention of COGnitive impairment (T-COG trial): a study protocol for a randomized, double-blind, placebo-controlled trial.. Front Nutr, 2025. RCT
- [4]Ingestion of taxifolin-rich foods affects brain activity, mental fatigue, and the whole blood transcriptome in healthy young adults (full text: participants and test food). Food & Function (RSC), 2023. RCT
What changed
- First draft. Every PMID checked against NCBI E-utilities (title, year and journal taken from the PubMed record) and abstracts read for each cited row. Product details in Where to buy read from the brand page on the date shown. Participant number and taxifolin dose for source 1 taken from the publisher’s full text. Self-reviewed in a second strict pass, then checked by an independent adversarial fact-check against the PubMed abstracts and live product pages. No credentialed medical reviewer yet.