Myricetin

Also called myricetin supplement, myricetin flavonol, bayberry myricetin.

Best grade D across 1 graded outcome Other Last checked

The short answer

From 7 sources

Myricetin is a plant flavonol sold alone and in combination products. It has never been tested by itself in a human trial: one 20-person pilot of a silymarin, PQQ and myricetin product reported lower blood alcohol after wine. Reviews note poor absorption, and no agency has reviewed its safety. It is a different compound from dihydromyricetin.

Quick pick

Source Naturals Myricetin, 100 mg, 60 tablets

from HerbsPro

Label: 1 tablet: 100 mg myricetin (from bayberry bark/leaf extract), plus 94 mg calcium.

Best for trying one bottle: $12.25 one-time (checked Oct 15, 2026).

Shop at HerbsPro (paid link, opens in new tab)

Partner links may earn us a commission. How partner links work

How we chose: Momentous is the partner brand we list first, so its product leads whenever the Where to buy list has one for this compound or a form in our Forms table. Otherwise, among partner brands that passed our vetting without conditions (others only when none sells it), the first product in that list whose name matches a form in our Forms table, else the first one listed. Not a claim that it works: check the amount per serving against the studied doses and limits.

Every graded outcome on this page

1 row · line = participants
  1. Grade DBlood alcohol and oxidative-stress markers after drinking wineAlcohol metabolismn 20

Key facts

What it is
A naturally occurring flavonol found abundantly in plant families such as Myricaceae, Anacardiaceae and Polygonaceae1
Absorption
Reviews describe limited bioavailability because of poor water solubility and extensive phase II metabolism (glucuronidation and sulfation)1
Human evidence
One 20-person single-blind pilot of a silymarin, PQQ and myricetin combination; no trial of myricetin alone in our sources2
Funding
The pilot was funded internally by the University of Padova and Italy's National Research Council (CNR); authors declared no conflicts2
Not dihydromyricetin
Dihydromyricetin (DHM), the flavonoid in Hovenia dulcis and Chinese vine tea used for hangovers, is a different compound with its own LiverTox entry4
Agency safety reviews
No ODS, NCCIH, LactMed, LiverTox, Health Canada or EMA source has an entry on myricetin itself3

What it is

Myricetin is a flavonol, a plant flavonoid found in families such as Myricaceae, Anacardiaceae and Polygonaceae.

How it works

Proposed

In laboratory studies myricetin acts on cellular pathways including Nrf2/HO-1, MAPK and PI3K/Akt and scavenges free radicals; reviews note it may also act as a pro-oxidant in the presence of metal ions. None of this has been tested in people taking myricetin alone.1

Forms, side by side

2 forms named in our sources. The rest show what our data holds, and say plainly where it holds nothing yet.

Myricetin forms compared

2 forms
Myricetin forms compared: 2 forms by 3 attributes. Empty cells are labelled No data yet, or Not graded in the evidence row.
2 formsTablets or capsulesCombination products (with silymarin and PQQ)
Absorption in peopleReviews describe poor water solubility and extensive phase II metabolism, which limit bioavailability.1No human absorption data in our sources.2
GI toleranceNo human trial of myricetin alone in our sources.1The pilot abstract does not report adverse events.2
Studied forNo single-ingredient human trial in our sourcesBlood alcohol and oxidative-stress markers after wine (20-person pilot)
  1. Myricetin tablets or capsules
    Absorption in people
    Reviews describe poor water solubility and extensive phase II metabolism, which limit bioavailability.1
    GI tolerance
    No human trial of myricetin alone in our sources.1
    Studied for
    No single-ingredient human trial in our sources
  2. Combination products (with silymarin and PQQ)
    Absorption in people
    No human absorption data in our sources.2
    GI tolerance
    The pilot abstract does not report adverse events.2
    Studied for
    Blood alcohol and oxidative-stress markers after wine (20-person pilot)
Every cell holds data from a cited page; citation numbers link to the page that holds them.Scroll the table for every column

What the human research says

Human trials only, one row per outcome. The form line shows what each trial actually tested. Grades follow our evidence-grading policy.

Trial map

1 graded outcome, largest study first

One graded outcome so far. Blood alcohol and oxidative-stress markers after drinking wine: a 2024 randomized trial of 20 people found an improvement.

1. Blood alcohol and oxidative-stress markers after drinking wine: improved, 20 people1

1Blood alcohol and oxidative-stress markers after drinking wine

Improved · Grade D · RCT, 20 people, 2024

Young adult wine drinkers (13 men, 7 women)

Dose, result and source
Every graded outcome on this page, largest study first
OutcomeFoundPeopleStudyWho was studied
Blood alcohol and oxidative-stress markers after drinking wineImproved20Grade D · RCT, 2024Young adult wine drinkers (13 men, 7 women)
Each circle is one graded outcome on this page, numbered from the largest study down, and placed by how many people it studied (log scale). It shows who was studied and what was found, not advice about your dose.

Every graded row

1 row
Grade DBlood alcohol and oxidative-stress markers after drinking wineAlcohol metabolismBlood alcohol -33% at 120 minRCT
n 20 · 2024

Improved Circulating ethanol was reduced by 33% at 120 minutes; total antioxidant capacity rose 9 to 12% and 8-isoprostane, a lipid-peroxidation marker, fell 22 to 27%. The authors call for further verification.

Design
RCT, n = 20, 2024
Population
Young adult wine drinkers (13 men, 7 women)
Form
Si.Pi.Mi., a combination of silymarin, pyrroloquinoline quinone (PQQ) sodium salt and myricetin
Dose
Not stated in the paper (a commercial drink mix of silymarin, Myrica cerifera extract and PQQ)
Duration
Single dose after wine, then 1 week with daily wine
Source
Reference 2 · PubMed 39275279 (opens PubMed)

Drug-interaction signals from lab and animal studies (preclinical)

3 notes

None of this has been tested in people. These are signals a human interaction study would need to check.

Ticagrelor (blood thinner)
In rat and human liver microsomes, myricetin inhibited ticagrelor's conversion to its main metabolite (IC50 about 18 µM in human microsomes), and in rats given both, ticagrelor blood levels (AUC and Cmax) rose significantly.5
Tofacitinib (arthritis drug)
In rat and human liver microsomes and in CYP3A4 enzyme variants, myricetin inhibited tofacitinib metabolism.7
Drug transporters and albumin
In cell studies, myricetin and its sulfate metabolite strongly inhibited the drug transporters OATP1B1 and OATP2B1 and moderately displaced warfarin from albumin, but had little or no effect on CYP2C9, CYP2C19 or CYP3A4.6

What the numbers add up to

Each point is worked out from the data and the sources numbered on this page, with the arithmetic shown under it. It adds no new data and is not medical advice.

No single-ingredient human data

The only human trial in our sources combined myricetin with silymarin and PQQ in 20 people, so no result can be credited to myricetin itself.2

How we got this: Intervention and size of the cited trial

Studied doses

Doses used in research, shown against the official limits. They describe the studies, not a recommendation for you.

Studied doses in research, not advice. These are amounts used in research, not personal advice. Your clinician or pharmacist can say what fits you.

Doses studied in human trials

Doses studied in human trials ranged from a single dose to 1 week of a silymarin, PQQ and myricetin combination, with the myricetin amount not stated in the paper; no trial gave myricetin alone.2

Interactions and safety

Published interactions only: each row cites a source. No row means none was found in our sources, not that a combination is safe.

What Myricetin meets

0 cited rows 2 tested together

Medicines 0

No medicine rows in our sources.

Myricetin0 medicines · 2 supplements

Supplements and foods 2

  • Tested together in a graded trial
Also cited: 2 tested together

  1. Milk ThistleMilk Thistle page

    • Tested together

      Blood alcohol and oxidative-stress markers after drinking wine. Graded on the Myricetin page; tested together is not a claim that they work better together.

  2. PQQPQQ page

    • Tested together

      Blood alcohol and oxidative-stress markers after drinking wine. Graded on the Myricetin page; tested together is not a claim that they work better together.

Rows as our evidence profiles cite them; links stay on this site. Line weight shows what backs a row, not how serious an interaction is. No line means none was found in our sources, not that a combination is safe. Not medical advice: ask your pharmacist.

Interactions

0 agents

None found in our sources.

Check with what you take

Kept on this device only

Add what you take. We list every interaction our evidence profiles cite between Myricetin and your picks, and between your picks.

Most cited:

Add a supplement or medicine you take to check it against Myricetin.

Starting from one medicine? The interaction checker rates how serious each pair is, on a curated list of 19 entries for 11 medicines. This cabinet has no severity rating: it lists every interaction row our supplement pages cite.

Not medical advice, and no dosing advice. An empty result means no row we cite names that pair, by name or through a drug class we can link the medicine to, not that a combination is safe. Where our sources name only a group of medicines we cannot match, the cabinet says so. Ask your pharmacist before you combine supplements and medicines.

Who should be careful

4 groups
Agency coverage
No ODS, NCCIH, LactMed, LiverTox, Health Canada or EMA source covers myricetin itself. LiverTox's entry on the related compound dihydromyricetin does not apply to myricetin.34
People on medicines
No human interaction study exists. In lab and rat studies myricetin slowed the breakdown of the blood thinner ticagrelor and the arthritis drug tofacitinib and blocked drug transporters (see the research notes). NCCIH advises telling your health care providers about any supplement you use.3567
Pregnancy, breastfeeding and children
No trial in our sources studied these groups, LactMed has no entry for myricetin, and NCCIH notes that many dietary supplements have not been tested in pregnant women, nursing mothers or children.3
Before surgery
NCCIH advises telling your health care providers about all supplements well before an operation.3
Talk to your pharmacist or clinician before starting a supplement, especially if you take prescription medicines.

How to read the label

What to check on the Supplement Facts panel.

How to read the label

3 checks
Myricetin vs DHM

Check the label: dihydromyricetin (DHM) products are a different compound from myricetin.4

No studied dose to match

The only human trial did not state how much myricetin its product contained, so no label amount can be compared with a tested dose.2

Check the whole blend

The tested product combined silymarin, PQQ and a Myrica cerifera (bayberry) extract as the myricetin source; results for that blend do not transfer to myricetin alone.2

Where to buy Myricetin

Products from brands we partner with that contain Myricetin. Check the amount per serving against the doses studied above, and the label for other ingredients.

Myricetin products from partner brands

1 product
  • Quick pickHerbsProSource Naturals Myricetin, 100 mg, 60 tablets

    1 tablet: 100 mg myricetin (from bayberry bark/leaf extract), plus 94 mg calcium

    $12.25one-timeChecked Oct 15, 2026
    Shop at HerbsPro (paid link, opens in new tab)

Listing a product is not a claim that it works; check the amount per serving against the doses studied, and the label for other ingredients.Prices and labels are from each brand’s own site on the date shown; confirm before you buy.

Partner links may earn us a commission. How partner links work

Frequently asked questions

Short answers to common questions; the numbers link to the sources below.

Common questions

7 answers
Does myricetin lower blood alcohol or help hangovers?

Unproven. One 20-person pilot of a silymarin, PQQ and myricetin product reported 33% lower circulating ethanol at 120 minutes, but myricetin was never tested alone and hangover symptoms were not the focus.2

Is myricetin safe?

No agency has reviewed myricetin, and the one human pilot abstract does not report side effects. NCCIH notes supplements may interact with medications.23

Does myricetin interact with medicines?

No human study has tested this. In lab and rat studies it slowed the breakdown of ticagrelor and tofacitinib and blocked drug transporters, which could in principle raise drug levels. Tell your health care providers if you use it with prescription medicines.3567

Is myricetin safe in pregnancy or while breastfeeding?

There are no data. No trial included pregnant or breastfeeding women, LactMed has no entry for myricetin, and NCCIH notes that many supplements have not been tested in these groups.3

Is myricetin the same as dihydromyricetin (DHM)?

No. DHM is a related flavonoid found in Hovenia dulcis and Chinese vine tea; it has its own LiverTox entry and its own research.4

Is myricetin well absorbed?

Reviews describe limited bioavailability because myricetin dissolves poorly in water and is heavily metabolised.1

What is myricetin?

A flavonol, a type of plant flavonoid found in families such as Myricaceae, Anacardiaceae and Polygonaceae.1

Sources

7 sources: trial abstracts, NIH fact sheets and reference databases. Numbers in the text link here.

Sources cited on this page

7 sources
  1. 1Unveiling the Health Potential of Myricetin: Bio-accessibility, Safety Considerations, and Therapeutic Mechanisms.Review Curr Pharm Des, 2026 · PMID 40739693
  2. 2Consumption of Sylimarin, Pyrroloquinoline Quinone Sodium Salt and Myricetin: Effects on Alcohol Levels and Markers of Oxidative Stress-A Pilot Study.RCT Nutrients, 2024 · PMID 39275279
  3. 3Using Dietary Supplements WiselyFact sheet National Center for Complementary and Integrative Health (NCCIH), 2019 · nccih.nih.gov
  4. 4Dihydromyricetin (LiverTox: Clinical and Research Information on Drug-Induced Liver Injury)Database National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), 2023 · ncbi.nlm.nih.gov
  5. 5Effects of myricetin and quercetin on ticagrelor metabolism and the underlying mechanism.Animal study Chem Biol Interact, 2024 · PMID 38401715
  6. 6Interaction of myricetin, ampelopsin (dihydromyricetin), and their sulfate metabolites with serum albumin, cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes, and organic anion-transporting polypeptides (OATP1B1 and OATP2B1).Lab study Pharmacol Res Perspect, 2024 · PMID 39344282
  7. 7CYP3A4 and CYP2C19 genetic polymorphisms and myricetin interaction on tofacitinib metabolism.Lab study Biomed Pharmacother, 2024 · PMID 38719708

What changed

Every dated change to this page: what changed, who made it and why.

Change log

2 entries
Dated changes to this page
DateChangeWho and why
evidence, safety, research notes, label guide, FAQEvidence row re-read in PMC full text (no myricetin amount stated; placebo contained 1 g vitamin C). Added preclinical drug-interaction research notes (PMIDs 38401715, 39344282, 38719708) and a safety note that no human interaction study exists; breastfeeding note states LactMed has no entry. Two label-guide steps and two FAQs added. PubMed searched 2023–2026: no other human trial of myricetin.Writer: Kymata Health EditorialTrigger: A–Z page audit
allInitial editorial evidence review. Every PMID checked against NCBI E-utilities esummary (title and year) and each cited abstract read; numbers taken from the abstracts (and, where noted, the full text for funding, product and participant details). Funding disclosed: the only trial was funded internally by the University of Padova and CNR (full text). No agency source covers myricetin, so safety text cites NCCIH's Using Dietary Supplements Wisely; LiverTox's dihydromyricetin entry is cited only to distinguish the two compounds. Where to buy: Source Naturals Myricetin 100 mg (product page and label checked 2026-10-15).Writer: Kymata Health EditorialTrigger: new page

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