Cannabigerol (CBG)

Also called CBG, hemp CBG, CBG isolate.

Best grade D across 3 graded outcomes Botanical Last checked Oct 21, 2026

The short answer

From 9 sources

Cannabigerol (CBG) is a minor hemp cannabinoid marketed for calm, focus and sleep. Human data are three small trials: 20 mg lowered anxiety and stress versus placebo in 34 healthy adults, single doses up to 200 mg showed no robust effects, and 25–50 mg daily for 4 weeks did not beat placebo for sleep in veterans (grade D).

Every graded outcome on this page

3 rows · line = participants

Grade DSleep quality, quality of life and PTSD symptomsSleepn 63
Grade DAnxiety, stress and mood after a single doseAnxietyn 34
Grade DSafety, subjective effects and blood levelsSafetyn 12

Key facts

What it is: A minor cannabinoid from hemp that does not produce a high at the doses tested^1,2
Anxiety and stress: A single 20 mg dose lowered anxiety and stress versus placebo in a 34-person crossover trial¹
Dose-ranging: Single doses of 25 to 200 mg were well tolerated in 12 adults, with no robust effects²
Sleep: In 63 veterans with sleep problems, 25 mg then 50 mg daily for 4 weeks improved sleep scores no more than placebo⁷
Sport: CBG is prohibited by WADA, and it was found in urine of people using a broad-spectrum CBD product³
Typical use: Surveyed users reported typical doses of 10 to 12 mg, mainly for sleep, pain and anxiety⁴

What it is

Cannabigerol (CBG) is a non-intoxicating cannabinoid from hemp, sold as an isolate or in broad-spectrum CBD products.

How it works

Proposed

CBG is a minor cannabinoid; animal studies suggested anti-anxiety and antidepressant effects, which prompted the first human trial. How it acts in people is not established, and in a dose-ranging study effects did not rise consistently with dose.^1,2

Forms, side by side

2 forms named in our sources. The rest show what our data holds, and say plainly where it holds nothing yet.

Cannabigerol (CBG) forms compared

2 forms

Cannabigerol (CBG) forms compared: 2 forms by 3 attributes. Empty cells are labelled No data yet, or Not graded in the evidence row.
2 forms	CBG isolate (oil or capsules)	Hemp-derived CBG tincture
Absorption in people	Blood levels rose in proportion to dose from 25 to 200 mg but varied widely between people. With a single 25 mg dose, a high-fat meal raised blood levels more than an emulsified formulation did.^2,8	No head-to-head human data.
GI tolerance	No drug-related adverse events and normal liver tests after single doses up to 200 mg.²	No subjective drug effects or impairment after 20 mg.¹
Studied for	Safety and blood levels	Acute anxiety and stress

CBG isolate (oil or capsules)
Absorption in people
Blood levels rose in proportion to dose from 25 to 200 mg but varied widely between people. With a single 25 mg dose, a high-fat meal raised blood levels more than an emulsified formulation did.^2,8
GI tolerance
No drug-related adverse events and normal liver tests after single doses up to 200 mg.²
Studied for
Safety and blood levels
Hemp-derived CBG tincture
Absorption in people
No head-to-head human data.
GI tolerance
No subjective drug effects or impairment after 20 mg.¹
Studied for
Acute anxiety and stress

What the human research says

Human trials only, one row per outcome. The form line shows what each trial actually tested. Grades follow our evidence-grading policy.

Trial map

3 graded outcomes, largest study first

3 graded outcomes: 1 improved, 2 no effect. The largest, a 2026 randomized trial of 63 people on sleep quality, quality of life and PTSD symptoms, found no effect.

By sizeTable

1Sleep quality, quality of life and PTSD symptoms

No effect · Grade D · RCT, 63 people, 2026

US veterans with sleep problems, enrolled remotely

Dose, result and source

Every graded outcome on this page, largest study first
Outcome	Found	People	Study	Who was studied
Sleep quality, quality of life and PTSD symptoms	No effect	63	Grade D · RCT, 2026	US veterans with sleep problems, enrolled remotely
Anxiety, stress and mood after a single dose	Improved	34	Grade D · Crossover RCT, 2024	Healthy adults, tested remotely over video (USA)
Safety, subjective effects and blood levels	No effect	12	Grade D · PK study, 2026	Healthy adults (USA)

Every graded row

3 rows

Grade DSleep quality, quality of life and PTSD symptomsSleepNo effectRCT
n 63 · 2026

No effect Sleep scores improved in both groups with no significant difference between CBG and placebo; quality-of-life and PTSD scores followed the same pattern. CBG was well tolerated.

Design: RCT, n = 63, 2026
Population: US veterans with sleep problems, enrolled remotely
Form: CBG tablets (25 mg)
Dose: 25 mg daily for 2 weeks, then 50 mg daily for 2 weeks
Duration: 4 weeks after a 2-week run-in
Source: Reference 7 · PubMed 41574318 (opens PubMed)

Grade DAnxiety, stress and mood after a single doseAnxietyImprovedCrossover RCT
n 34 · 2024

Improved Anxiety was lower overall and stress lower at the first time point than with placebo, and verbal memory was better. There were no subjective drug effects or impairment.

Design: Crossover RCT, n = 34, 2024
Population: Healthy adults, tested remotely over video (USA)
Form: Hemp-derived CBG tincture
Dose: 20 mg single dose vs placebo
Duration: Two sessions one week apart
Source: Reference 1 · PubMed 39003387 (opens PubMed)

Grade DSafety, subjective effects and blood levelsSafetyNo effectPK study
n 12 · 2026

No effect No drug-related adverse events and no liver test above normal. Subjective effects were minimal and inconsistent (less jittery at 50 mg, less calm at 100 mg, more appetite at 200 mg); blood levels rose with dose but varied widely between people.

Design: PK study, n = 12, 2026
Population: Healthy adults (USA)
Form: CBG isolate in MCT oil
Dose: Single ascending doses of 25, 50, 100 and 200 mg, plus placebo
Duration: Single doses, 8 hours of sampling each
Source: Reference 2 · PubMed 42575778 (opens PubMed)

What the numbers add up to

Each point is worked out from the data and the sources numbered on this page, with the arithmetic shown under it. It adds no new data and is not medical advice.

Two studies, opposite impressions

A 20 mg dose lowered anxiety in a remote field trial, but a lab study of 25 to 200 mg found minimal and inconsistent subjective effects, even a drop in calm at 100 mg.^1,2

Studied doses

Doses used in research, shown against the official limits. They describe the studies, not a recommendation for you.

Studied doses in research, not advice. These are amounts used in research, not personal advice. Your clinician or pharmacist can say what fits you.

Doses studied in human trials

Doses studied in human trials ranged from 20 to 200 mg: single doses of 20 mg of a hemp-derived tincture (anxiety) and 25, 50, 100 and 200 mg of isolate in oil (safety and blood levels), and 25 mg daily for 2 weeks then 50 mg daily for 2 weeks in a sleep trial in veterans.^1,2,7

When trials measured an effect

1 outcome

How long trials ran before effects were measured
Outcome	Measured at	Basis
Anxiety and stress in healthy adults	Within the same session, shortly after a single 20 mg dose	Stress was lower than with placebo at the first rating after dosing; anxiety was lower across the session¹

Interactions and safety

Published interactions only: each row cites a source. No row means none was found in our sources, not that a combination is safe.

What Cannabigerol meets

1 cited row

Medicines 1

Cannabigerol1 medicine · 0 supplements

Supplements and foods 0

No supplement rows in our sources.

Measured in a human study

Interactions

1 agent

Published interactions, grouped by kind
Agent	What the source says	Evidence
Medicines1
Medicines cleared by liver CYP enzymese.g. drugs metabolized by CYP3A4, CYP2D6, CYP2C8 or CYP2C9	In lab and mouse studies, CBG was rapidly broken down by the human liver enzymes CYP3A4, CYP2D6, CYP2C8, CYP2C9 and CYP2J2, which also clear many medicines. No human interaction study appears in our sources, so the size of any effect is unknown.⁵	PK study

Check with what you take

Kept on this device only

Add what you take. We list every interaction our evidence profiles cite between Cannabigerol and your picks, and between your picks.

Add a supplement or medicine

Most cited:

Add a supplement or medicine you take to check it against Cannabigerol.

Starting from one medicine? The interaction checker rates how serious each pair is, on a curated list of 19 entries for 11 medicines. This cabinet has no severity rating: it lists every interaction row our supplement pages cite.

Who should be careful

4 groups

Athletes in tested sports: WADA prohibits cannabinoids other than CBD, including CBG, and CBG appeared in the urine of 42 to 74% of people using a broad-spectrum CBD product.³
Legal status (United States): Hemp-derived CBG is sold under the 2018 farm bill's hemp definition. A November 2025 federal law narrows that definition from November 12, 2026, excluding final products with more than 0.4 mg of total THC per container and cannabinoids made outside the plant; state laws also differ.⁶
Pregnancy, breastfeeding and children: No study has enrolled pregnant or breastfeeding women or children, and LactMed has no CBG entry. The FDA strongly advises against CBD, THC and marijuana in any form during pregnancy or breastfeeding and warns of possible risks from cannabis products.^9,1,2,7
Long-term use: The longest trial lasted 4 weeks (25 mg, then 50 mg daily) and found CBG well tolerated; longer use has not been studied.^7,2

Reading the label, and the cost per dose

Compare any product you already have by the amount it delivers, not by capsule count or front-of-pack weight.

How to read the label

2 checks

Label dose vs studied dose

Surveyed users typically take 10 to 12 mg, below the 20 mg single dose that lowered anxiety in the one placebo-controlled trial.^1,4

Broad-spectrum CBD contains CBG

Broad-spectrum CBD products can contain trace CBG that shows up in urine tests.³

Have the bottle? Photograph its Supplement Facts panel and see each line, cannabigerol (cbg) included, beside the doses and forms the trials used in Label X-Ray.

Cost per studied dose, without the sales pitch

Your numbers, no product data

Price paid ($)Servings per containerCBG per serving (mg)

Compare against

Enter the price, servings and the amount per serving from your label.

Frequently asked questions

Short answers to common questions; the numbers link to the sources below.

Common questions

6 answers

Does CBG help anxiety?

In one crossover trial, a single 20 mg dose lowered anxiety and stress versus placebo in 34 healthy adults. No trial has tested repeated use or people with anxiety disorders.¹

Does CBG help you sleep?

Not on current evidence. In a 4-week trial in 63 veterans with sleep problems, 25 mg then 50 mg daily improved sleep scores no more than placebo. The trial was smaller than planned, and its lead author works for the sponsor company.⁷

Does CBG get you high?

No subjective drug effects or impairment were found after 20 mg, and effects were minimal at single doses up to 200 mg.^1,2

Is CBG safe?

Single doses up to 200 mg caused no drug-related adverse events or liver test abnormalities in 12 adults, and 25–50 mg daily for 4 weeks was well tolerated in 63 veterans. Use beyond 4 weeks has not been studied.^2,7

What is the difference between CBG and CBD?

Both are hemp cannabinoids. WADA allows CBD but prohibits CBG, and CBG has only three small human trials in our sources.^3,1,2,7

Can CBG fail a drug test?

CBG is on WADA's prohibited list, and it was detected in urine of people using a broad-spectrum CBD product, more so after exercise. THC was not detected in that study.³

Sources

9 sources: trial abstracts, NIH fact sheets and reference databases. Numbers in the text link here.

Sources cited on this page

9 sources

1Acute effects of cannabigerol on anxiety, stress, and mood: a double-blind, placebo-controlled, crossover, field trial.Crossover RCT Sci Rep, 2024 · PMID 39003387
2Safety, pharmacodynamics, and pharmacokinetics of oral cannabigerol in healthy adults.PK study J Pharmacol Exp Ther, 2026 · PMID 42575778
3Daily Use of a Broad-Spectrum Cannabidiol Supplement Produces Detectable Concentrations of Cannabinoids in Urine Prohibited by the World Anti-Doping Agency: An Effect Amplified by Exercise.RCT Med Sci Sports Exerc, 2026 · PMID 40920736
4A Survey of Cannabigerol User's Patterns of Use, Perceived Efficacy and Satisfaction.Observational J Psychoactive Drugs, 2026 · PMID 42741890
5Metabolites of Cannabigerol Generated by Human Cytochrome P450s Are Bioactive.Animal study Biochemistry, 2022 · PMID 36223199
6Change to Federal Definition of Hemp and Implications for Federal Enforcement (CRS Insight IN12620)Fact sheet Congressional Research Service, 2025 · congress.gov
7Effect of Cannabigerol on Sleep and Quality of Life in Veterans: A Decentralized, Randomized, Placebo-Controlled Trial.RCT Med Cannabis Cannabinoids, 2026 · PMID 41574318
8Impact of Dietary Fat and Oral Delivery System on Cannabigerol Pharmacokinetics in Adults.PK study Cannabis Cannabinoid Res, 2024 · PMID 38574248
9What You Should Know About Using Cannabis, Including CBD, When Pregnant or Breastfeeding (content current as of October 16, 2019)Safety communication U.S. Food and Drug Administration, 2019 · fda.gov

What changed

Every dated change to this page: what changed, who made it and why.

Change log

4 entries

Dated changes to this page
Date	Change	Who and why
Oct 21, 2026summary, key facts, evidence, studied doses, forms, who should avoid, time to effect, FAQ, questions, related	Added a 2026 randomized trial of CBG for sleep in 63 veterans (no difference from placebo, grade D; n from full text) and a 2024 study showing a high-fat meal raises CBG absorption. Pregnancy note now cites the FDA consumer update on cannabis in pregnancy and breastfeeding (LactMed and LiverTox have no CBG entry). Interactions re-checked: still no human interaction study (LiverTox, LactMed and PubMed searched). Added a sleep FAQ, time to effect, page questions and related links. Not added: a 2023 recovery trial of a CBD, CBG and amino acid blend (37947792; effects cannot be attributed to CBG) and an unblinded 2026 pain study of mixed cannabinoid capsules (42140793).	Writer: Kymata Health EditorialTrigger: A–Z audit against docs/supplements/AUDIT-STANDARD.md
Oct 17, 2026safety	Independent review: added a US legal-status note (CRS summary of P.L. 119-37) and a possible drug-interaction note based on CBG's metabolism by human CYP enzymes (PubMed-verified).	Writer: Kymata Health EditorialTrigger: review
Oct 17, 2026all	First draft. Every PMID checked against NCBI E-utilities esummary (title and year taken from the record) and abstracts read for every cited row.	Writer: Kymata Health EditorialTrigger: new page
Oct 17, 2026all	Adversarial review pass: every evidence row's numbers machine-checked against its PubMed abstract, retraction and erratum flags checked for all PMIDs, unverified country and affiliation details removed, and claims not supported by the cited abstracts reworded or dropped.	Writer: Kymata Health EditorialTrigger: review

Supplement & Nutrient Encyclopedia. Educational information only; it is not medical advice and does not replace a clinician. Dietary supplements are not intended to diagnose, treat, cure or prevent any disease. Statements about supplements have not been evaluated by the FDA.

Cannabigerol (CBG)

Medicines 1

Supplements and foods 0

Medicines cleared by liver CYP enzymes