ProHealth Longevity review: NMN, NMNH and the healthy-aging lineup, checked against the research
ProHealth has sold supplements since 1988 and is now one of the largest NAD+ specialists, with Uthever NMN, UthPeak NMNH and its own lower-priced Essentials line. We read every label, matched doses to the trials and priced every serving.
Our verdict
- Best for: NAD+ buyers who want branded NMN at trial doses, a budget line, and per-product lab results they can read before buying.
- Standout: a Certificate of Analysis on every product we checked, a 100-day money-back guarantee, and Subscribe & Save up to 30%.
- Watch out for: several products ahead of the human evidence (NMNH, fisetin, Ca-AKG), marketing claims stronger than the trials, and no sport certification (NSF or Informed Sport).
ProHealth Longevity offers
20% off your first order
- New customers only.
- Excludes bulk products (100 g, 250 g, 500 g, 1 kg), packs and test kits.
- Not available with previous purchases or other offers.
- Up to 30% off regular prices on select items.
- Subscribe & Save prices cannot be combined with other discounts or special offers unless specified.
- The first-order discount and Subscribe & Save are separate offers; we don’t claim they combine.
- Offer terms from ProHealth Longevity’s site and its affiliate program, checked Oct 7, 2026. Offers can change; the brand's checkout is final.
Who ProHealth Longevity is
ProHealth was founded in 1988 by Rich Carson and sells under the ProHealth Longevity name from Carpinteria, California. It focuses on NAD+ precursors (NMN, NMNH, NR) and other healthy-aging compounds.
The company says its products are made in FDA-registered, GMP-certified US facilities, tested three times by independent labs, and backed by a 100-day satisfaction guarantee. It publishes a Certificate of Analysis on each product page.
- Founded
- 1988 by Rich Carson source
- Based in
- Carpinteria, California (ProHealth, Inc.) source
- Lab results
- Certificate of Analysis on each product page source
- Guarantee
- 100-day satisfaction guarantee (shipping not refunded) source
- First order
- 20% off with the newsletter coupon (new customers; exclusions apply) source
- Subscription
- Subscribe & Save up to 30% (10% or 30% on the products we list) source
Testing and certifications
ProHealth says every product is tested three times by independent third-party labs and publishes a Certificate of Analysis on each product page we checked. It does not carry NSF Certified for Sport or Informed Sport certification, which matters mainly for drug-tested athletes.
- Triple lab testing: "Rigorously tested three times by independent third-party labs" (product pages). source
- Certificates of Analysis: A per-product CoA (image or PDF) on all 14 product pages we list. source
- Manufacturing: Made in FDA-registered, GMP-certified facilities in the USA (brand statement). source
- Sport certifications: No NSF Certified for Sport or Informed Sport certification found on prohealth.com (checked Oct 8, 2026). source
ProHealth Longevity lineup at a glance
| Product | Label dose | Evidence | Per serving |
|---|---|---|---|
| NMN Pro 1000 (Uthever) | Uthever β-nicotinamide mononucleotide (NMN) 1,000 mg | B · moderate | $2.17 |
| NMN Pro 500 (Uthever) | Uthever β-nicotinamide mononucleotide (NMN) 500 mg | B · moderate | $1.43 |
| Essentials NMN 1000 (Nexergy) | Nexergy nicotinamide mononucleotide (NMN) 1,000 mg | B · moderate | $1.33 |
| Pure NMNH 250 (UthPeak) | UthPeak NMNH (dihydronicotinamide mononucleotide) 250 mg | D · preliminary | $1.60 |
| Essentials NMNH 500 (Nexergy+) | Nexergy+ NMNH 500 mg | D · preliminary | $2.20 |
| Nicotinamide Riboside Pro 300 + TMG | Nicotinamide riboside (as NR hydrogen malate) 300 mg; TMG 100 mg | C · limited | $0.83 |
| NMN Pro Complete powder | Uthever NMN 1,000 mg; Veri-te trans-resveratrol 1,000 mg; TMG 500 mg | C · limited | $2.77 |
| TMG Pro Tablets | Trimethylglycine (betaine anhydrous) 1,000 mg | B · moderate | $0.14 |
| Full Spectrum Urolithin A | StanYouth urolithin A 500 mg; Pomanox pomegranate extract 250 mg; muscadine grape skin and seed extract 100 mg | B · moderate | $2.67 |
| Pure Spermidine 1 mg | Spermidine (from wheat germ extract) 1 mg | C · limited | $0.17 |
| Pure Fisetin 250 mg | Fisetin 250 mg per capsule | D · preliminary | $0.93 |
| Calcium AKG Longevity | Calcium alpha-ketoglutarate 1,000 mg (provides 180 mg calcium) | D · preliminary | $0.84 |
| Brain-Mag Pro (Magtein) | Magnesium 144 mg from 2,000 mg Magtein magnesium L-threonate | B · moderate | $1.11 |
| Creatine Pure Powder | Creavitalis creatine monohydrate 5 g | A · strong | $0.56 |
Every product, label vs research
NAD+ precursor
ProHealth Longevity NMN Pro 1000 (Uthever)
Uthever-brand NMN (the brand states 99.5% purity), 1,000 mg per two-capsule serving.
- On the label · per 2 capsules
- Uthever β-nicotinamide mononucleotide (NMN) 1,000 mg
- What the research used
- 300–900 mg/day for 60 days in 80 healthy middle-aged adults (blood NAD+ highest at 600 and 900 mg); 250 mg/day in smaller trials. 1,000 mg is just above the top studied dose.
Evidence: B · moderate. Randomized trials show NMN raises blood NAD+ dose-dependently; effects on function are modest and mixed so far (the 60-day trial also reported a longer 6-minute walk).
Who it fits: Adults who want a branded-ingredient NMN at a dose at or above the trials. Cheaper than per-serving NMNH.
$2.17/serving$64.95 for 30 servings · $58.46 with subscription ($1.95/serving) · checked Oct 8, 2026
NAD+ precursor
ProHealth Longevity NMN Pro 500 (Uthever)
Uthever NMN, 500 mg in one capsule.
- On the label · per 1 capsule
- Uthever β-nicotinamide mononucleotide (NMN) 500 mg
- What the research used
- 300–900 mg/day in the 60-day dose-response trial; 500 mg sits between the 300 and 600 mg arms.
Evidence: B · moderate. Same evidence as NMN Pro 1000, at a mid-range trial dose.
Who it fits: People starting NMN who want one capsule a day.
$1.43/serving$42.95 for 30 servings · $38.66 with subscription ($1.29/serving) · checked Oct 8, 2026
NAD+ precursor (value line)
ProHealth Longevity Essentials NMN 1000 (Nexergy)
ProHealth’s lower-priced NMN line, using its own Nexergy NMN ingredient instead of Uthever.
- On the label · per 2 capsules
- Nexergy nicotinamide mononucleotide (NMN) 1,000 mg
- What the research used
- Same NMN trials as above (300–900 mg/day). No trial has tested the Nexergy ingredient specifically.
Evidence: B · moderate. NMN evidence applies to NMN generally; the CoA is how you check this ingredient’s purity.
Who it fits: Budget-minded NMN users: the lowest price per serving for 1,000 mg in ProHealth’s range.
$1.33/serving$39.95 for 30 servings · $35.96 with subscription ($1.20/serving) · checked Oct 8, 2026
NAD+ precursor (next-gen)
ProHealth Longevity Pure NMNH 250 (UthPeak)
UthPeak NMNH (reduced NMN), from the makers of Uthever.
- On the label · per 1 capsule
- UthPeak NMNH (dihydronicotinamide mononucleotide) 250 mg
- What the research used
- Cell and mouse studies only in PubMed; we found no peer-reviewed human trial of NMNH (searched Oct 8, 2026).
Evidence: D · preliminary. Lab data show NMNH raises NAD+ strongly in cells and mice. Human evidence is not yet published in peer-reviewed form, so we grade it preliminary.
Who it fits: Early adopters who accept preliminary evidence and a higher price per mg than NMN.
$1.60/serving$47.95 for 30 servings · $43.16 with subscription ($1.44/serving) · checked Oct 8, 2026
NAD+ precursor (next-gen)
ProHealth Longevity Essentials NMNH 500 (Nexergy+)
ProHealth’s own amorphous Nexergy+ NMNH at 500 mg per capsule.
- On the label · per 1 capsule
- Nexergy+ NMNH 500 mg
- What the research used
- No peer-reviewed human NMNH trial found; dose chosen by the brand.
Evidence: D · preliminary. Graded on preclinical data, as for Pure NMNH.
Who it fits: NMNH users who want a higher dose per capsule.
$2.20/serving$65.95 for 30 servings · $59.36 with subscription ($1.98/serving) · checked Oct 8, 2026
NAD+ precursor
ProHealth Longevity Nicotinamide Riboside Pro 300 + TMG
Nicotinamide riboside (as NR hydrogen malate) with a little TMG.
- On the label · per 1 capsule
- Nicotinamide riboside (as NR hydrogen malate) 300 mg; TMG 100 mg
- What the research used
- NR raised blood NAD+ at 1,000 mg/day (500 mg twice daily) in middle-aged and older adults. Note: the trials used NR chloride, not the hydrogen-malate salt.
Evidence: C · limited. NR reliably raises NAD+ in blood; 300 mg is below the studied 1,000 mg/day, and functional benefits are not yet clear.
Who it fits: People who want the cheapest entry to NAD+ precursors, ideally at more than one capsule a day.
$0.83/serving$24.95 for 30 servings · $17.47 with subscription ($0.58/serving) · checked Oct 8, 2026
NAD+ combination
ProHealth Longevity NMN Pro Complete powder
One scoop combining Uthever NMN, Veri-te trans-resveratrol and TMG (no other ingredients).
- On the label · per 1 scoop (2.5 g)
- Uthever NMN 1,000 mg; Veri-te trans-resveratrol 1,000 mg; TMG 500 mg
- What the research used
- NMN as above (300–900 mg/day). The NMN + resveratrol + TMG combination has not been trialed in people.
Evidence: C · limited. The NMN component is trial-backed; the rationale for adding resveratrol and TMG comes from mechanism and animal work.
Who it fits: People already taking all three who want one scoop. Resveratrol may interact with blood thinners; ask first if you take them.
$2.77/serving$82.95 for 30 servings · $74.66 with subscription ($2.49/serving) · checked Oct 8, 2026
Methyl donor
ProHealth Longevity TMG Pro Tablets
Trimethylglycine (betaine anhydrous), often paired with NMN by longevity enthusiasts.
- On the label · per 1 tablet
- Trimethylglycine (betaine anhydrous) 1,000 mg
- What the research used
- A meta-analysis found at least 4 g/day of betaine for 6+ weeks lowered plasma homocysteine in healthy adults. One tablet is a quarter of that.
Evidence: B · moderate. Good evidence that betaine lowers homocysteine at 4–6 g/day; the case for pairing it with NMN is theoretical.
Who it fits: NMN users who like the methyl-donor rationale. Very low cost per tablet.
$0.14/serving$16.57 for 120 servings · $11.60 with subscription ($0.10/serving) · checked Oct 8, 2026
Mitochondrial health
ProHealth Longevity Full Spectrum Urolithin A
StanYouth urolithin A with pomegranate (Pomanox) and muscadine grape extracts.
- On the label · per 2 capsules
- StanYouth urolithin A 500 mg; Pomanox pomegranate extract 250 mg; muscadine grape skin and seed extract 100 mg
- What the research used
- 500–1,000 mg/day of urolithin A for 4 weeks to 4 months in older and middle-aged adults (muscle strength and endurance, mitochondrial markers). Those trials used Mitopure, a different supplier’s urolithin A.
Evidence: B · moderate. Randomized trials report better muscle endurance or strength and mitochondrial biomarkers at 500–1,000 mg/day; primary endpoints were not always met.
Who it fits: Adults over 40 focused on muscle and energy who want the studied 500 mg dose at a lower price than the trial brand.
$2.67/serving$79.95 for 30 servings · $55.97 with subscription ($1.87/serving) · checked Oct 8, 2026
Autophagy support
ProHealth Longevity Pure Spermidine 1 mg
Wheat-germ-derived spermidine (not synthetic), 1 mg per capsule.
- On the label · per 1 capsule
- Spermidine (from wheat germ extract) 1 mg
- What the research used
- 0.9 mg/day of wheat-germ spermidine for 12 months in 100 adults aged 60–90 (SmartAge trial).
Evidence: C · limited. The 12-month trial found no change in its primary memory outcome or biomarkers versus placebo; exploratory signals need confirming.
Who it fits: People who want to try spermidine at the trial dose and accept a null main result. Contains wheat (check if you avoid gluten).
$0.17/serving$29.95 for 180 servings · $20.97 with subscription ($0.12/serving) · checked Oct 8, 2026
Senolytic (experimental)
ProHealth Longevity Pure Fisetin 250 mg
Fisetin from Rhus succedanea stem extract, sold for short high-dose cycles.
- On the label · per 1 capsule (brand protocol: 1,500 mg on short cycles)
- Fisetin 250 mg per capsule
- What the research used
- Senolytic doses come from mouse studies and ongoing clinical trials; we found no completed, peer-reviewed human trial showing a benefit.
Evidence: D · preliminary. Animal data only for the senolytic use; graded preliminary.
Who it fits: Experimenters only. Discuss high-dose cycles with a clinician, especially if you take other medicines.
$0.93/serving$55.95 for 60 servings · $39.17 with subscription ($0.65/serving) · checked Oct 8, 2026
Healthy aging
ProHealth Longevity Calcium AKG Longevity
Calcium alpha-ketoglutarate, a Krebs-cycle compound studied in aging research.
- On the label · per 2 capsules
- Calcium alpha-ketoglutarate 1,000 mg (provides 180 mg calcium)
- What the research used
- The human data are a retrospective analysis of 42 people taking a different AKG formula (with vitamins) for about 7 months; no randomized trial of Ca-AKG alone was found.
Evidence: D · preliminary. Most evidence is from worms and mice; the human report was uncontrolled.
Who it fits: Experimenters. Count the 180 mg of calcium toward your daily calcium.
$0.84/serving$25.25 for 30 servings · $17.68 with subscription ($0.59/serving) · checked Oct 8, 2026
Sleep and cognition
ProHealth Longevity Brain-Mag Pro (Magtein)
Magtein magnesium L-threonate, the same branded form Momentous uses.
- On the label · per 3 capsules
- Magnesium 144 mg from 2,000 mg Magtein magnesium L-threonate
- What the research used
- 2 g/day Magtein for 6 weeks (100 adults with poor sleep) and 1 g/day for 21 days (80 adults aged 35–55). The label matches the 2 g trial.
Evidence: B · moderate. Small, short randomized trials reported better sleep-tracker and cognitive-test scores than placebo.
Who it fits: The lowest-priced Magtein we list. Ask first if you have kidney disease.
$1.11/serving$33.28 for 30 servings · $29.95 with subscription ($1.00/serving) · checked Oct 8, 2026
Strength and healthy aging
ProHealth Longevity Creatine Pure Powder
Creavitalis creatine monohydrate powder, 450 g tub.
- On the label · per 1 scoop (5 g)
- Creavitalis creatine monohydrate 5 g
- What the research used
- 3–5 g a day; in postmenopausal women, gains showed up at 5 g/day with resistance training.
Evidence: A · strong. The most-studied sports supplement; strong evidence for strength and lean mass with training.
Who it fits: Healthy-aging buyers who want creatine from the same store as their NAD+ products.
$0.56/serving$49.95 for 90 servings · $44.96 with subscription ($0.50/serving) · checked Oct 8, 2026
Pros and cons
What we like
- A Certificate of Analysis on every product page we checked, plus a 100-day guarantee.
- Branded ingredients (Uthever NMN, UthPeak NMNH, Magtein, Veri-te resveratrol) and a cheaper Essentials line for the same compounds.
- NMN at or above trial doses for well under $2 a serving, and the lowest-priced Magtein we list.
- Subscribe & Save up to 30% and 20% off a first order through the newsletter.
What to watch
- Several products are ahead of the human evidence: NMNH, fisetin and calcium AKG are graded D.
- Marketing copy on some pages goes further than the trials; read our grades rather than the bottle claims.
- No NSF Certified for Sport or Informed Sport certification.
- Urolithin A uses a different supplier than the brand behind the published trials.
Safety notes
- NAD+ precursors are well tolerated in trials of up to a few months; long-term data are limited.
- Resveratrol (in NMN Pro Complete) may interact with blood thinners and some other medicines.
- High-dose fisetin cycles have no human safety data at the brand’s suggested dose; talk to a clinician first.
- Calcium AKG adds 180 mg calcium per serving; magnesium products: ask first if you have kidney disease.
- Supplements can interact with prescription medicines. Check with your doctor or pharmacist before starting.
Alternatives and related guides
FAQ
Is ProHealth NMN legit?
ProHealth publishes a Certificate of Analysis on each product page, uses branded Uthever NMN in its Pro line, and has sold supplements since 1988. NMN itself has moderate evidence for raising blood NAD+ (grade B).
NMN or NMNH: which should I buy?
NMN has randomized human trials; NMNH has only cell and animal data in peer-reviewed journals so far. We grade NMN B and NMNH D, so NMN is the evidence-first choice today.
Is there a ProHealth discount code?
ProHealth gives new newsletter subscribers 20% off a first order (exclusions: bulk sizes, packs, test kits), and Subscribe & Save saves 10% or 30% on the products we list. Offers do not combine.
Is ProHealth third-party tested?
ProHealth says each product is tested three times by independent labs and posts a Certificate of Analysis on every product page we checked. It does not hold NSF Certified for Sport or Informed Sport certification.
Sources
Label doses, prices and certifications come from ProHealth Longevity's own product pages, read Oct 8, 2026. Studies were checked on PubMed the same day.
- Yi L et al. NMN supplementation in healthy middle-aged adults: randomized, dose-dependent trial. GeroScience 2023. · PMID 36482258
- Igarashi M et al. Chronic NMN supplementation in healthy older men. NPJ Aging 2022. · PMID 35927255
- Liu Y et al. Reduced nicotinamide mononucleotide (NMNH) potently enhances NAD+ (cell study). J Proteome Res 2021. · PMID 33793246
- Martens CR et al. Chronic nicotinamide riboside supplementation in middle-aged and older adults. Nat Commun 2018. · PMID 29599478
- McRae MP. Betaine supplementation decreases plasma homocysteine: meta-analysis. J Chiropr Med 2013. · PMID 23997720
- Singh A et al. Urolithin A and muscle strength in middle-aged adults: randomized trial. Cell Rep Med 2022. · PMID 35584623
- Liu S et al. Urolithin A, muscle endurance and mitochondrial health in older adults. JAMA Netw Open 2022. · PMID 35050355
- Andreux PA et al. Urolithin A first-in-human trial. Nat Metab 2019. · PMID 32694802
- Schwarz C et al. Spermidine and cognition in older adults (SmartAge). JAMA Netw Open 2022. · PMID 35616942
- Demidenko O et al. Rejuvant (AKG formulation) and DNA methylation age: retrospective analysis. Aging 2021. · PMID 34847066
- Magnesium L-threonate (Magtein) on cognition and sleep: randomised trial. Front Nutr 2025. · PMID 41601871
- Hausenblas HA et al. Magnesium L-threonate and sleep quality: randomized trial. Sleep Med X 2024. · PMID 39252819
- Kreider RB et al. ISSN position stand: creatine supplementation. J Int Soc Sports Nutr 2017. · PMID 28615996
- Creatine monohydrate in postmenopausal women: systematic review and meta-analysis. J Int Soc Sports Nutr 2026. · PMID 42141930
- ProHealth: Our story
- ProHealth: Return policy and guarantee
- ProHealth: Subscribe & Save terms
- ProHealth: Newsletter first-order offer